Title : Severe growth deficiency is associated with STAT5b mutations that disrupt protein folding and activity.

Pub. Date : 2013 Jan

PMID : 23160480






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Unlike STAT5b(A630P), which showed minimal GH-induced tyrosine phosphorylation and no transcriptional activity, STAT5b(F646S) became tyrosine phosphorylated after GH treatment and could function as a GH-activated transcription factor, although to a substantially lesser extent than STAT5b(WT). Tyrosine signal transducer and activator of transcription 5B Homo sapiens
2 Unlike STAT5b(A630P), which showed minimal GH-induced tyrosine phosphorylation and no transcriptional activity, STAT5b(F646S) became tyrosine phosphorylated after GH treatment and could function as a GH-activated transcription factor, although to a substantially lesser extent than STAT5b(WT). Tyrosine signal transducer and activator of transcription 5B Homo sapiens