Dasatinib

ABL proto-oncogene 1, non-receptor tyrosine kinase ; Homo sapiens







407 Article(s)
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201 23238683 All tyrosine kinase inhibitor-resistant chronic myelogenous cells are highly sensitive to ponatinib. 2012 Dec 1
202 25031941 Interpreting molecular monitoring results and international standardization in chronic myeloid leukemia. 2012 May 1
203 20473616 Successful pregnancy involving a man with chronic myeloid leukemia on dasatinib. 2011 Jan 1
204 20807497 A magnetic bead-based protein kinase assay with dual detection techniques. 2011 Jan 1 1
205 20942869 An investigation of reversal of imatinib resistance in the Bcr-Abl positive imatinib-resistant cell line K562r by dasatinib, nilotinib, rapamycin and bortezomib. 2011 Apr 2
206 20945321 Long-term outcomes in the second-line treatment of chronic myeloid leukemia: a review of tyrosine kinase inhibitors. 2011 Mar 1 1
207 20952511 p57Kip2 is a downstream effector of BCR-ABL kinase inhibitors in chronic myelogenous leukemia cells. 2011 Jan 1
208 20962097 Variola and monkeypox viruses utilize conserved mechanisms of virion motility and release that depend on abl and SRC family tyrosine kinases. 2011 Jan 1
209 21098337 Targeting the BCR-ABL signaling pathway in therapy-resistant Philadelphia chromosome-positive leukemia. 2011 Jan 15 1
210 21148814 Disruption of Src function potentiates Chk1-inhibitor-induced apoptosis in human multiple myeloma cells in vitro and in vivo. 2011 Feb 10 1
211 21220945 Impact of BCR-ABL mutations on patients with chronic myeloid leukemia. 2011 Jan 15 2
212 21226671 Dasatinib: an anti-tumour agent via Src inhibition. 2011 Apr 2
213 21263099 Pediatric phase I trial and pharmacokinetic study of dasatinib: a report from the children's oncology group phase I consortium. 2011 Mar 1 1
214 21264552 A novel insertion mutation of K294RGG within BCR-ABL kinase domain confers imatinib resistance: sequential analysis of the clonal evolution in a patient with chronic myeloid leukemia in blast crisis. 2011 Feb 3
215 21385851 Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation. 2011 May 12 1
216 21454413 Epigenetic silencing of microRNA-203 dysregulates ABL1 expression and drives Helicobacter-associated gastric lymphomagenesis. 2011 May 15 1
217 21463117 The potential for dasatinib in treating chronic lymphocytic leukemia, acute myeloid leukemia, and myeloproliferative neoplasms. 2011 May 2
218 21505103 The ABL switch control inhibitor DCC-2036 is active against the chronic myeloid leukemia mutant BCR-ABLT315I and exhibits a narrow resistance profile. 2011 May 1 1
219 21528941 Activity and safety of dasatinib as second-line treatment or in newly diagnosed chronic phase chronic myeloid leukemia patients. 2011 Jun 1 1
220 21575924 Managing Philadelphia chromosome-positive acute lymphoblastic leukemia: role of tyrosine kinase inhibitors. 2011 Apr 1
221 21632458 Choosing the best second-line tyrosine kinase inhibitor in imatinib-resistant chronic myeloid leukemia patients harboring Bcr-Abl kinase domain mutations: how reliable is the IC₅₀? 2011 1
222 21633166 Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. 2011 Jul 1
223 21654685 HOXC11-SRC-1 regulation of S100beta in cutaneous melanoma: new targets for the kinase inhibitor dasatinib. 2011 Jun 28 1
224 21660654 Role of tyrosine kinase inhibitors in the management of Philadelphia chromosome-positive acute lymphoblastic leukemia. 2011 Sep 1
225 21670084 Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors. 2011 Sep 1 1
226 21718141 Tyrosine kinase inhibitor resistance in chronic myeloid leukemia cell lines: investigating resistance pathways. 2011 Nov 1
227 21792346 Moving on up: Second-Line Agents as Initial Treatment for Newly-Diagnosed Patients with Chronic Phase CML. 2011 2
228 21863287 RCSD1-ABL1-positive B lymphoblastic leukemia is sensitive to dexamethasone and tyrosine kinase inhibitors and rapidly evolves clonally by chromosomal translocations. 2011 Sep 1
229 21902298 Dasatinib: a review of its use in the treatment of chronic myeloid leukaemia and Philadelphia chromosome-positive acute lymphoblastic leukaemia. 2011 Sep 10 3
230 21908430 The BCR-ABL35INS insertion/truncation mutant is kinase-inactive and does not contribute to tyrosine kinase inhibitor resistance in chronic myeloid leukemia. 2011 Nov 10 1
231 21931113 Dasatinib as first-line treatment for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. 2011 Dec 15 1
232 21990409 Sensitive detection of BCR-ABL1 mutations in patients with chronic myeloid leukemia after imatinib resistance is predictive of outcome during subsequent therapy. 2011 Nov 10 1
233 22035738 Outcome of treatment of chronic myeloid leukemia with second-generation tyrosine kinase inhibitors after imatinib failure. 2011 Jun 1
234 22087818 Effects of BCR-ABL inhibitors on anti-tumor immunity. 2011 2
235 19768693 Dynamic change of T315I BCR-ABL kinase domain mutation in Korean chronic myeloid leukaemia patients during treatment with Abl tyrosine kinase inhibitors. 2010 Jun 1
236 19798095 Choosing the best treatment strategy for chronic myeloid leukemia patients resistant to imatinib: weighing the efficacy and safety of individual drugs with BCR-ABL mutations and patient history. 2010 Jan 1
237 19924787 Dasatinib 100 mg once daily minimizes the occurrence of pleural effusion in patients with chronic myeloid leukemia in chronic phase and efficacy is unaffected in patients who develop pleural effusion. 2010 Jan 15 1
238 20001232 Current treatment options for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. 2010 Feb 1
239 20038231 Use of dasatinib and nilotinib in imatinib-resistant chronic myeloid leukemia: translating preclinical findings to clinical practice. 2010 Mar 1
240 20047099 Successful prior treatment with dasatinib followed by stem cell transplantation in a patient with CML in blastic crisis with a BCR-ABL mutation. 2010 Jan 2
241 20072833 Dasatinib. 2010 3
242 20072840 Danusertib (formerly PHA-739358)--a novel combined pan-Aurora kinases and third generation Bcr-Abl tyrosine kinase inhibitor. 2010 1
243 20108303 Phase 1 pharmacokinetic and drug-interaction study of dasatinib in patients with advanced solid tumors. 2010 Mar 15 2
244 20111071 Development of resistance to dasatinib in Bcr/Abl-positive acute lymphoblastic leukemia. 2010 Apr 5
245 20113198 Dasatinib in solid tumors. 2010 Mar 1
246 20139391 Potent, transient inhibition of BCR-ABL with dasatinib 100 mg daily achieves rapid and durable cytogenetic responses and high transformation-free survival rates in chronic phase chronic myeloid leukemia patients with resistance, suboptimal response or intolerance to imatinib. 2010 Feb 2
247 20139893 Glyoxalase-I is a novel target against Bcr-Abl+ leukemic cells acquiring stem-like characteristics in a hypoxic environment. 2010 Jul 1
248 20143399 The BCR/ABL-inhibitors imatinib, nilotinib and dasatinib differentially affect NK cell reactivity. 2010 Nov 1 3
249 20145167 Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias. 2010 Feb 15 2
250 20197479 New developments in tyrosine kinase inhibitor therapy for newly diagnosed chronic myeloid leukemia. 2010 Mar 15 1