Pub. Date : 2010
PMID : 20072833
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It potently inhibits BCR-ABL and SRC-family kinases (SRC, LCK, YES, FYN), but also c-KIT, PDGFR-alpha and beta, and ephrin receptor kinase.Dasatinib is about 300 times more potent than imatinib in cells expressing unmutated BCR-ABL in vitro. | Dasatinib | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | It potently inhibits BCR-ABL and SRC-family kinases (SRC, LCK, YES, FYN), but also c-KIT, PDGFR-alpha and beta, and ephrin receptor kinase.Dasatinib is about 300 times more potent than imatinib in cells expressing unmutated BCR-ABL in vitro. | Dasatinib | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 3 | The drug has demonstrated activity against clinically relevant mutations, including those associated with poor prognosis during ongoing imatinib therapy.Dasatinib is approved for the treatment of patients with BCR-ABL-positive chronic myeloid leukemia (CML), resistant or intolerant to imatinib in chronic, accelerated, and blast phase. | Dasatinib | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |