Dasatinib

ABL proto-oncogene 1, non-receptor tyrosine kinase ; Homo sapiens







407 Article(s)
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151 23433665 Frequency of ABL gene mutations in chronic myeloid leukemia patients resistant to imatinib and results of treatment switch to second-generation tyrosine kinase inhibitors. 2013 Aug 4 1
152 23466625 Combining dasatinib with dexamethasone long-term leads to maintenance of antiviral and antileukemia specific cytotoxic T cell responses in vitro. 2013 Jul 1
153 23569389 Systematic review of dasatinib in chronic myeloid leukemia. 2013 1
154 23576564 Threshold levels of ABL tyrosine kinase inhibitors retained in chronic myeloid leukemia cells determine their commitment to apoptosis. 2013 Jun 1 2
155 23630094 Chromothripsis in Hodgkin lymphoma. 2013 Aug 1
156 23701117 A phosphoproteomics approach to identify candidate kinase inhibitor pathway targets in lymphoma-like primary cell lines. 2013 Dec 1
157 23715577 Dasatinib in children and adolescents with relapsed or refractory leukemia: results of the CA180-018 phase I dose-escalation study of the Innovative Therapies for Children with Cancer Consortium. 2013 Jul 1 1
158 23815902 [Efficacy of dasatinib in treatment of imatinib-resistant BCR/ABL positive leukemia]. 2013 Jun 4
159 23816609 Through the open door: Preferential binding of dasatinib to the active form of BCR-ABL unveiled by in silico experiments. 2013 Oct 7
160 23906052 New insights into biology of chronic myeloid leukemia: implications in therapy. 2013 Sep 1
161 23942795 The development of dasatinib as a treatment for chronic myeloid leukemia (CML): from initial studies to application in newly diagnosed patients. 2013 Dec 4
162 24007855 Impressive thrombocytosis evolving in a patient with a BCR-ABL positive CML in major molecular response during dasatinib treatment unmasks an additional JAK2V617F. 2013 Sep 5 1
163 24072218 Phase II study of dasatinib (BMS-354825) in patients with metastatic adenocarcinoma of the pancreas. 2013 1
164 24095296 A critical review of trials of first-line BCR-ABL inhibitor treatment in patients with newly diagnosed chronic myeloid leukemia in chronic phase. 2013 Dec 1
165 24130846 A target-disease network model of second-generation BCR-ABL inhibitor action in Ph+ ALL. 2013 1
166 24137941 [Therapeutic strategy for chronic myeloid leukemia: possibilities and prospects]. 2013 1
167 24155950 Combination of bortezomib and mitotic inhibitors down-modulate Bcr-Abl and efficiently eliminates tyrosine-kinase inhibitor sensitive and resistant Bcr-Abl-positive leukemic cells. 2013 1
168 24236021 Ponatinib is a pan-BCR-ABL kinase inhibitor: MD simulations and SIE study. 2013 1
169 24240798 Dasatinib-responsive chronic lymphocytic leukemia in a patient treated for coexisting chronic myeloid leukemia. 2013 2
170 24385789 Dasatinib May Override F317L BCR-ABL Kinase Domain Mutation in Patients with Chronic Myeloid Leukemia. 2013 Jun 1
171 24729782 Enhanced Ca2+Entry and Tyrosine Phosphorylation Mediate Nanostructure-Induced Endothelial Proliferation. 2013 Oct 6 1
172 21717440 Measuring response to BCR-ABL inhibitors in chronic myeloid leukemia. 2012 Jan 15 1
173 21751967 Inhibition of cell growth and up-regulation of MAD2 in human oesophageal squamous cell carcinoma after treatment with the Src/Abl inhibitor dasatinib. 2012 Jan 1
174 21844872 Evolving treatment strategies for patients newly diagnosed with chronic myeloid leukemia: the role of second-generation BCR-ABL inhibitors as first-line therapy. 2012 Feb 1
175 21874302 The immune inhibitory receptor osteoactivin is upregulated in monocyte-derived dendritic cells by BCR-ABL tyrosine kinase inhibitors. 2012 Feb 1
176 22089930 Enhanced ABL-inhibitor-induced MAPK-activation in T315I-BCR-ABL-expressing cells: a potential mechanism of altered leukemogenicity. 2012 Feb 1
177 22160483 Dasatinib or imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION). 2012 Feb 2 2
178 22233429 Spotlight on dasatinib in chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. 2012 Feb 1 4
179 22262141 Successful treatment of a chronic-phase T-315I-mutated chronic myelogenous leukemia patient with a combination of imatinib and interferon-alfa. 2012 Feb 1
180 22262776 Targeting of GSK3β promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells. 2012 Mar 8 1
181 22285209 Dasatinib: from treatment of imatinib-resistant or -intolerant patients with chronic myeloid leukemia to treatment of patients with newly diagnosed chronic phase chronic myeloid leukemia. 2012 Feb 1
182 22344285 Intracellular protein trafficking kinetics in chronic myeloid leukemia stem cells using a microfluidic platform. 2012 Apr 2
183 22419518 Enhancement of natural killer cell effector functions against selected lymphoma and leukemia cell lines by dasatinib. 2012 Sep 15 1
184 22428569 Fluorescence-based experimental model to evaluate the concomitant effect of drugs on the tumour microenvironment and cancer cells. 2012 Jun 1
185 22493660 Structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the Abl tyrosine kinase domain. 2012 1
186 22538170 Oxidative stress is involved in Dasatinib-induced apoptosis in rat primary hepatocytes. 2012 Jun 15 1
187 22554713 Second-generation tyrosine kinase inhibitors reduce telomerase activity in K562 cells. 2012 Oct 28 3
188 22587422 Pharmacokinetics of dasatinib for Philadelphia-positive acute lymphocytic leukemia with acquired T315I mutation. 2012 May 15 2
189 22591714 The CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target in gastric cancer. 2012 Jul 3 1
190 22689211 Complete morphologic and molecular remission after introduction of dasatinib in the treatment of a pediatric patient with t-cell acute lymphoblastic leukemia and ABL1 amplification. 2012 Aug 3
191 22815843 Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells. 2012 1
192 22846973 Comparison of the effects of two kinase inhibitors, sorafenib and dasatinib, on chronic lymphocytic leukemia cells. 2012 1
193 22874537 Dasatinib inhibits leukaemic cell survival by decreasing PRH/Hhex phosphorylation resulting in increased repression of VEGF signalling genes. 2012 Nov 1
194 22956142 An in vitro screening to identify drug-resistant mutations for target-directed chemotherapeutic agents. 2012 2
195 22985168 Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I. 2012 Sep 17 2
196 22992064 Dasatinib for the treatment of Philadelphia chromosome-positive leukemias. 2012 Nov 1
197 23010482 Dasatinib, a multi-kinase inhibitor increased radiation sensitivity by interfering with nuclear localization of epidermal growth factor receptor and by blocking DNA repair pathways. 2012 Nov 1
198 23049975 c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis. 2012 2
199 23090888 Chronic myeloid leukemia: 2012 update on diagnosis, monitoring, and management. 2012 Nov 1
200 23138519 Simultaneous determination of methotrexate, dasatinib and its active metabolite N- deshydroxyethyl dasatinib in rat plasma by LC-MS/MS: method validation and application to pharmacokinetic study. 2012 Dec 2