Title : Variola and monkeypox viruses utilize conserved mechanisms of virion motility and release that depend on abl and SRC family tyrosine kinases.

Pub. Date : 2011 Jan

PMID : 20962097






1 Functional Relationships(s)
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1 While inhibitors of both Src and Abl family kinases, such as dasatinib (BMS-354825; Sprycel), are effective in limiting dissemination of VacV, VarV, and MPX in vitro, members of this class of drugs appear to have immunosuppressive effects in vivo that preclude their use as anti-infectives. Dasatinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens