Metformin

protein kinase AMP-activated catalytic subunit alpha 2 ; Homo sapiens







339 Article(s)
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251 23414799 Fluorinated N,N'-diarylureas as AMPK activators. 2013 Mar 15 2
252 23620395 Maintenance of endothelial guanosine triphosphate cyclohydrolase I ameliorates diabetic nephropathy. 2013 Jun 2
253 23801715 AMPK: a target for drugs and natural products with effects on both diabetes and cancer. 2013 Jul 1
254 23835523 Molecular mechanism of action of metformin: old or new insights? 2013 Sep 3
255 23841933 AMP-activated protein kinase counteracts brain-derived neurotrophic factor-induced mammalian target of rapamycin complex 1 signaling in neurons. 2013 Oct 1
256 23904524 Metformin inhibits growth of eutopic stromal cells from adenomyotic endometrium via AMPK activation and subsequent inhibition of AKT phosphorylation: a possible role in the treatment of adenomyosis. 2013 Oct 6
257 23933835 Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression. 2013 Nov 4
258 23935921 Activation of AMPK inhibits cholera toxin stimulated chloride secretion in human and murine intestine. 2013 2
259 23942093 Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma. 2013 Oct 1 5
260 24265196 The multifaceted activities of AMPK in tumor progression--why the "one size fits all" definition does not fit at all? 2013 Nov 3
261 21567395 AMP-activated protein kinase inhibits TGF-β-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300. 2012 Mar 1
262 22333578 Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells. 2012 Mar 1 2
263 22378068 Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy. 2012 Mar 1 4
264 22378745 A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. 2012 Jul 1 4
265 22406476 Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. 2012 Jun 1
266 22459208 Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells. 2012 May 1 1
267 22492524 Cellular responses to the metal-binding properties of metformin. 2012 Jun 3
268 22561086 A potential mechanism of metformin-mediated regulation of glucose homeostasis: inhibition of Thioredoxin-interacting protein (Txnip) gene expression. 2012 Aug 2
269 22644486 Metformin interacts with AMPK through binding to γ subunit. 2012 Sep 9
270 22694351 Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation. 2012 Aug 2
271 22821946 Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation. 2012 Sep 15 1
272 22994747 Metformin inhibits growth of hepatocellular carcinoma cells by inducing apoptosis via mitochondrion-mediated pathway. 2012 1
273 23653852 Anti-angiogenic Effects of Metformin, an AMPK Activator, on Human Umbilical Vein Endothelial Cells and on Granulation Tissue in Rat. 2012 Nov 5
274 20965713 Activated AMPK and prostaglandins are involved in the response to conjugated linoleic acid and are sufficient to cause lipid reductions in adipocytes. 2011 Jul 2
275 21111758 AMPK and vasculoprotection. 2011 Aug 1
276 21114978 Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt. 2011 Jan 25 4
277 21228273 Hyaluronan synthesis is inhibited by adenosine monophosphate-activated protein kinase through the regulation of HAS2 activity in human aortic smooth muscle cells. 2011 Mar 11 3
278 21265739 AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer. 2011 Jan 1
279 21318055 AMPK as Target for Intervention in Childhood and Adolescent Obesity. 2011 1
280 21325438 Sensing of energy and nutrients by AMP-activated protein kinase. 2011 Apr 2
281 21455728 AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study. 2011 Jul 10
282 21470048 Stimulation of cardiomyogenesis of embryonic stem cells by nitric oxide downstream of AMP-activated protein kinase and mTOR signaling pathways. 2011 Dec 1
283 21619869 AMPK induces MUC5B expression via p38 MAPK in NCI-H292 airway epithelial cells. 2011 Jun 17 4
284 21740847 Beneficial effects of metformin on primary cardiomyocytes via activation of adenosine monophosphate-activated protein kinase. 2011 Jun 2
285 21849490 Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia. 2011 Dec 4
286 21945753 [Effect of metformin on apoptosis of renal cell carcinoma cells in vitro and its mechanisms]. 2011 Sep 1
287 21947382 Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status. 2011 Dec 7
288 22071265 Adenosine monophosphate-activated protein kinase: a central regulator of metabolism with roles in diabetes, cancer, and viral infection. 2011 1
289 22180679 A novel cardioprotective agent in cardiac transplantation: metformin activation of AMP-activated protein kinase decreases acute ischemia-reperfusion injury and chronic rejection. 2011 Dec 3
290 19617399 AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells. 2010 Jun 2
291 19625456 AMPK as a mediator of hormonal signalling. 2010 Feb 1
292 20123087 Metformin induces suppression of NAD(P)H oxidase activity in podocytes. 2010 Mar 5 5
293 20126541 Metabolic regulation of neuronal plasticity by the energy sensor AMPK. 2010 Feb 1 1
294 20135346 Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells. 2010 Aug 6
295 20363874 AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation. 2010 Jun 3
296 20498500 [Role of hypothalamic AMP-activated protein kinase in the control of food intake]. 2010 May 21 1
297 20577046 An energetic tale of AMPK-independent effects of metformin. 2010 Jul 3
298 20599746 AMP-activated kinase (AMPK)-generated signals in malignant melanoma cell growth and survival. 2010 Jul 16 1
299 20610860 Metformin-induced regulation of the intestinal D-glucose transporters. 2010 Jun 2
300 20615625 Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells. 2010 Sep 1 3