Title : Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells.

Pub. Date : 2012 Mar 1

PMID : 22333578






2 Functional Relationships(s)
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1 The indirect and direct activation of AMPK with the antidiabetic biguanide metformin and the thienopyridone A-769662, respectively, impeded the reprogramming of mouse embryonic and human diploid fibroblasts into iPSCs. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
2 Treatment with metformin or A-769662 before the generation of iPSC colonies was sufficient to drastically decrease iPSC generation, suggesting that AMPK activation impedes early stem cell genetic reprogramming. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens