Pub. Date : 2011 Jan 25
PMID : 21114978
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | Metformin is an antidiabetic drug with anticancer properties, which mainly acts through induction of AMP-activated protein kinase (AMPK). | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | Metformin is an antidiabetic drug with anticancer properties, which mainly acts through induction of AMP-activated protein kinase (AMPK). | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | In conclusion, the antidiabetic drug metformin reduces cisplatin in vitro anticancer activity through AMPK-independent upregulation of Akt survival pathway. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |