Pub. Date : 2013 Oct 1
PMID : 23942093
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To define the mechanisms of anticancer effects of metformin, we examined its influence on AMPK activation and NF-kappaB pathway. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | Activation of AMPK by metformin not only inhibited HCC cells growth in vitro and in vivo, but also augmented cisplatin-induced growth inhibition in HCC cells. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | Knockdown of AMPKalpha expression can greatly decrease the inhibitory effect of metformin, indicating that AMPK activation is required for the anticancer action of metformin. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | Knockdown of AMPKalpha expression can greatly decrease the inhibitory effect of metformin, indicating that AMPK activation is required for the anticancer action of metformin. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 5 | Mechanistically, metformin/AMPK activation inhibited NF-kappaB signaling through upregulation of IkappaBalpha. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |