Pub. Date : 2012 Jul 1
PMID : 22378745
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | Metformin induced activation of AMPK and SIRT1 and decreased p53 protein abundance. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | The decrease in p53 abundance caused by metformin was abolished by inhibition of murine double minute 2 (MDM2), a ubiquitin ligase that mediates p53 degradation, as well as by overexpression of a dominant-negative AMPK or a shRNA-mediated knockdown of SIRT1. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | In addition, overexpression of p53 decreased SIRT1 gene expression and protein abundance, as well as AMPK activity in metformin-treated cells. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |