Title : A potential mechanism of metformin-mediated regulation of glucose homeostasis: inhibition of Thioredoxin-interacting protein (Txnip) gene expression.

Pub. Date : 2012 Aug

PMID : 22561086






2 Functional Relationships(s)
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1 Moreover, we show that the effect of metformin on Txnip gene transcription is due to the inhibition of mitochondrial complex I and increased glycolysis, and is partially mediated by the AMP activated kinase (AMPK). Metformin protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
2 Moreover, we show that the effect of metformin on Txnip gene transcription is due to the inhibition of mitochondrial complex I and increased glycolysis, and is partially mediated by the AMP activated kinase (AMPK). Metformin protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens