Tyrosine

signal transducer and activator of transcription 3 ; Homo sapiens







754 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 34687791 Induction of IL-6Rα by ATF3 enhances IL-6 mediated sorafenib and regorafenib resistance in hepatocellular carcinoma. 2022 Jan 1 1
2 34857889 Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer. 2022 Feb 1
3 35072342 Cell fate-inducing CARs orthogonally control multiple signaling pathways. 2022 May 1
4 35200033 Telocinobufagin Has Antitumor Effects in Non-Small-Cell Lung Cancer by Inhibiting STAT3 Signaling. 2022 Apr 22 1
5 35397475 STAT3 is a biologically relevant therapeutic target in H3K27M-mutant diffuse midline glioma. 2022 Apr 9 2
6 35489748 Dimethyl Fumarate Induces Apoptosis via Inhibiting NF-κB and STAT3 Signaling in Adult T-cell Leukemia/Lymphoma Cells. 2022 May 1
7 32868906 10,11-dehydrocurvularin exerts antitumor effect against human breast cancer by suppressing STAT3 activation. 2021 May 1
8 33217668 Eucannabinolide, a novel sesquiterpene lactone, suppresses the growth, metastasis and BCSCS-like traits of TNBC via inactivation of STAT3. 2021 Jan 1
9 33262462 STAT3 phosphorylation at Ser727 and Tyr705 differentially regulates the EMT-MET switch and cancer metastasis. 2021 Jan 1
10 33382511 STAT3 and its targeting inhibitors in osteosarcoma. 2021 Feb 1
11 33689932 Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors. 2021 Apr 15 1
12 33818016 Increased Melanoma-Associated Antigen C2 Expression Affords Resistance to Apoptotic Deathin Suspension-Cultured Tumor Cells. 2021 Apr 1
13 33901593 Signal transducer and activator of transcription 3 (STAT3) acts as a proviral factor for dengue virus propagation. 2021 Jul 15 1
14 33909625 A novel small molecule LLL12B inhibits STAT3 signaling and sensitizes ovarian cancer cell to paclitaxel and cisplatin. 2021 1
15 34118143 Baicalein modulates the radiosensitivity of cervical cancer cells in vitro via miR-183 and the JAK2/STAT3 signaling pathway. 2021 Jul 4
16 34235865 The role of understudied post-translational modifications for the behavior and function of Signal Transducer and Activator of Transcription 3. 2021 Jul 8 1
17 34260805 Prostacyclin is an endosteal bone marrow niche component and its clinical analog iloprost protects hematopoietic stem cell potential during stress. 2021 Nov 1
18 34329662 Mutant IDH1 inhibitors activate pSTAT3-Y705 leading to an increase in BCAT1 and YKL-40 levels in mutant IDH1-expressing cells. 2021 Oct 1
19 34390807 The anti-parallel dimer binding interface in STAT3 transcription factor is required for the inactivation of cytokine-mediated signal transduction. 2021 Nov 1
20 34440160 The Roles of Post-Translational Modifications in STAT3 Biological Activities and Functions. 2021 Aug 4 1
21 34563576 The crystal structure of the domain-swapped dimer of onconase highlights some catalytic and antitumor activity features of the enzyme. 2021 Nov 30 1
22 34684783 Acacetin Inhibits the Growth of STAT3-Activated DU145 Prostate Cancer Cells by Directly Binding to Signal Transducer and Activator of Transcription 3 (STAT3). 2021 Oct 14 2
23 34699606 Zinc induces reactive astrogliosis through ERK-dependent activation of Stat3 and promotes synaptic degeneration. 2021 Dec 2
24 34703823 STAT3 as a Potential Target for Tumor Suppressive Effects of 15-Deoxy-Δ12,14-prostaglandin J2 in Triple Negative Breast Cancer. 2021 Sep 30 3
25 34731785 STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications. 2021 Dec 1
26 34884773 Opposing Effects of Chelidonine on Tyrosine and Serine Phosphorylation of STAT3 in Human Uveal Melanoma Cells. 2021 Nov 30 1
27 31499589 LL1, a novel and highly selective STAT3 inhibitor, displays anti-colorectal cancer activities in vitro and in vivo. 2020 Jan 3
28 31678681 TCDD-mediated suppression of naïve human B cell IgM secretion involves aryl hydrocarbon receptor-mediated reduction in STAT3 serine 727 phosphorylation and is restored by interferon-γ. 2020 Jan 1
29 31900385 DDIAS promotes STAT3 activation by preventing STAT3 recruitment to PTPRM in lung cancer cells. 2020 Jan 2 4
30 31956373 Nicotine Upregulates the Level of Mcl-1 through STAT3 in H1299 Cells. 2020 1
31 31963765 Pharmacological Inhibition of Oncogenic STAT3 and STAT5 Signaling in Hematopoietic Cancers. 2020 Jan 18 1
32 31982491 LYW-6, a novel cryptotanshinone derived STAT3 targeting inhibitor, suppresses colorectal cancer growth and metastasis. 2020 Mar 1
33 32030510 The PI3K pathway impacts stem gene expression in a set of glioblastoma cell lines. 2020 Mar 1
34 32032581 The putative endogenous AHR ligand ITE reduces JAG1 and associated NOTCH1 signaling in triple negative breast cancer cells. 2020 Apr 1
35 32201262 Constitutive STAT3 Serine Phosphorylation Promotes Helicobacter-Mediated Gastric Disease. 2020 Jun 1
36 32207811 Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome. 2020 Jun 1 1
37 32231398 Identification of novel regulators of STAT3 activity. 2020 1
38 32298693 Blocking STAT3 by pyrvinium pamoate causes metabolic lethality in KRAS-mutant lung cancer. 2020 Jul 1
39 32439998 TraPS-VarI: Identifying genetic variants altering phosphotyrosine based signalling motifs. 2020 May 21 2
40 32598086 A77 1726, the active metabolite of the anti-rheumatoid arthritis drug leflunomide, inhibits influenza A virus replication in vitro and in vivo by inhibiting the activity of Janus kinases. 2020 Aug 1
41 33042115 TLT2 Suppresses Th1 Response by Promoting IL-6 Production in Monocyte Through JAK/STAT3 Signal Pathway in Tuberculosis. 2020 1
42 33053804 An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H-Ras-Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target. 2020 Oct 12 1
43 33066004 Isolinderalactone Induces Cell Death via Mitochondrial Superoxide- and STAT3-Mediated Pathways in Human Ovarian Cancer Cells. 2020 Oct 13 1
44 33123602 Hypoxia Impairs NK Cell Cytotoxicity through SHP-1-Mediated Attenuation of STAT3 and ERK Signaling Pathways. 2020 1
45 30375708 2'-Hydroxycinnamaldehyde inhibits proliferation and induces apoptosis via signal transducer and activator of transcription 3 inactivation and reactive oxygen species generation. 2019 Jan 1
46 30631031 Atorvastatin Prevents Myocardial Fibrosis in Spontaneous Hypertension via Interleukin-6 (IL-6)/Signal Transducer and Activator of Transcription 3 (STAT3)/Endothelin-1 (ET-1) Pathway. 2019 Jan 11 2
47 30659097 Hepatitis B virus X protein-induced SH2 domain-containing 5 (SH2D5) expression promotes hepatoma cell growth via an SH2D5-transketolase interaction. 2019 Mar 29 1
48 30668440 Arctiin is a pharmacological inhibitor of STAT3 phosphorylation at tyrosine 705 residue and potentiates bortezomib-induced apoptotic and anti-angiogenic effects in human multiple myeloma cells. 2019 Mar 1 2
49 30675525 Robustness and Information Transfer within IL-6-induced JAK/STAT Signalling. 2019 1
50 30709346 2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells. 2019 Feb 1 1