Title : Cell fate-inducing CARs orthogonally control multiple signaling pathways.

Pub. Date : 2022 May

PMID : 35072342






1 Functional Relationships(s)
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1 We utilize signaling domains derived from natural receptors (gp130, RANK, c-Fms, and Fas) and tyrosine motif-engineered artificial signaling domains that preferentially recruit target signaling molecules (Shc and STAT3) for inducing specific cell fates by the CARs. Tyrosine signal transducer and activator of transcription 3 Homo sapiens