Title : Calpain-mediated proteolytic production of free amino acids in vascular endothelial cells augments obesity-induced hepatic steatosis.

Pub. Date : 2022 Apr 18

PMID : 35447117






1 Functional Relationships(s)
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1 Furthermore, conditioned media derived from calpain-activated ECs facilitated the phosphorylation of ribosomal protein S6 kinase (S6K) and de novo lipogenesis in hepatocytes, which were abolished by the amino acid transporter inhibitor, JPH203, and the mTORC1 inhibitor, rapamycin. Sirolimus ribosomal protein S6 kinase B1 Homo sapiens