Pub. Date : 2019 Sep
PMID : 31404320
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rapamycin enhanced the antitumor effects of doxorubicin in myelogenous leukemia K562 cells by downregulating the mTOR/p70S6K pathway. | Sirolimus | ribosomal protein S6 kinase B1 | Homo sapiens |
| 2 | The aim of the present study was to investigate the effects of rapamycin and doxorubicin on K562 cell proliferation following the combination treatment, and further focus on confirming whether rapamycin enhanced the antitumor effects of doxorubicin by downregulating the mTOR/ribosomal protein S6 kinase (p70S6K) pathway. | Sirolimus | ribosomal protein S6 kinase B1 | Homo sapiens |
| 3 | Rapamycin and doxorubicin also reduced the phosphorylation levels of mTOR and p70S6K. | Sirolimus | ribosomal protein S6 kinase B1 | Homo sapiens |
| 4 | These results suggested that rapamycin could enhance the antitumor effects of doxorubicin on K562 cells by downregulating mTOR/p70S6K signaling. | Sirolimus | ribosomal protein S6 kinase B1 | Homo sapiens |