endothelial PAS domain protein 1 ; Rattus norvegicus






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1 10559262 EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. J Biol Chem 1999 Nov 19 1
2 11257444 Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells. Cell Signal 2001 Jan 1
3 12089367 Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. J Am Soc Nephrol 2002 Jul 1
4 12490539 Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB J 2003 Feb 1
5 12679337 Induction of T-type calcium channel gene expression by chronic hypoxia. J Biol Chem 2003 Jun 20 2
6 12805361 Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation. J Biol Chem 2003 Aug 22 3
7 15879294 Developmental changes in HIF transcription factor in carotid body: relevance for O2 sensing by chemoreceptors. Pediatr Res 2005 Jul 2
8 17125738 Non-hypoxic induction of HIF-3alpha by 2-deoxy-D-glucose and insulin. Biochem Biophys Res Commun 2007 Jan 12 1
9 17627993 HIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle. J Physiol 2007 Sep 1 1
10 17967803 Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model. Nephrol Dial Transplant 2008 Apr 1
11 18353899 Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line. Am J Physiol Cell Physiol 2008 Jun 10
12 19457096 Hypoxia inducible factor (HIF)-2 alpha is required for the development of the catecholaminergic phenotype of sympathoadrenal cells. J Neurochem 2009 Jul 4
13 19494136 Chronic nicotine blunts hypoxic sensitivity in perinatal rat adrenal chromaffin cells via upregulation of KATP channels: role of alpha7 nicotinic acetylcholine receptor and hypoxia-inducible factor-2alpha. J Neurosci 2009 Jun 3 1
14 19671538 Cyclic AMP represses the hypoxic induction of hypoxia-inducible factors in PC12 cells. J Biochem 2009 Dec 2
15 20228418 Spironolactone, but not enalapril, potentiates hypoxia-inducible factor-1 alpha and Ets-1 expression in newborn rat kidney. J Physiol Pharmacol 2010 Feb 1
16 21232037 Role of hypoxia-inducible factors in the dexrazoxane-mediated protection of cardiomyocytes from doxorubicin-induced toxicity. Br J Pharmacol 2011 May 1
17 21346155 Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2{alpha}) in intestinal epithelial cells. Am J Physiol Cell Physiol 2011 Jun 1
18 21436314 Hypoxia-inducible factor-2α and iron absorptive gene expression in Belgrade rat intestine. Am J Physiol Gastrointest Liver Physiol 2011 Jul 2
19 21753061 Hypoxia inducible factor-2 α is translationally repressed in response to dietary iron deficiency in Sprague-Dawley rats. J Nutr 2011 Sep 3
20 22403787 Chronic nicotine induces hypoxia inducible factor-2α in perinatal rat adrenal chromaffin cells: role in transcriptional upregulation of KATP channel subunit Kir6.2. Am J Physiol Cell Physiol 2012 May 15 3
21 22495609 Chronic and intermittent hypoxia differentially regulate left ventricular inflammatory and extracellular matrix responses. Hypertens Res 2012 Aug 1
22 22884965 HIF-3α mRNA expression changes in different tissues and their role in adaptation to intermittent hypoxia and physical exercise. Pathophysiology 2012 Jun 1
23 22890185 Rebamipide attenuates pain severity and cartilage degeneration in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes. Osteoarthritis Cartilage 2012 Nov 1
24 22970249 Hypoxic induction of the regulator of G-protein signalling 4 gene is mediated by the hypoxia-inducible factor pathway. PLoS One 2012 1
25 23065129 Sildenafil alleviates bronchopulmonary dysplasia in neonatal rats by activating the hypoxia-inducible factor signaling pathway. Am J Respir Cell Mol Biol 2013 Jan 2
26 23174565 Copper stabilizes the Menkes copper-transporting ATPase (Atp7a) protein expressed in rat intestinal epithelial cells. Am J Physiol Cell Physiol 2013 Feb 1 1
27 23545307 Cellular overexpression of aquaporins slows down the natural HIF-2α degradation during prolonged hypoxia. Gene 2013 Jun 10 2
28 23814049 Transcription factors Sp1 and Hif2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epithelial cells during hypoxia. J Biol Chem 2013 Aug 16 2
29 23962064 Hypoxia-inducible factors promote alveolar development and regeneration. Am J Respir Cell Mol Biol 2014 Jan 1
30 24124516 Xanthine oxidase mediates hypoxia-inducible factor-2α degradation by intermittent hypoxia. PLoS One 2013 4
31 24898587 Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A. Am J Physiol Cell Physiol 2014 Aug 1 3
32 24973414 Regulation of hypoxia-inducible factor-α isoforms and redox state by carotid body neural activity in rats. J Physiol 2014 Sep 1 1
33 25447307 Differential contribution of key metabolic substrates and cellular oxygen in HIF signalling. Exp Cell Res 2015 Jan 1 3
34 25715026 Increased expression of HIF2α during iron deficiency-associated megakaryocytic differentiation. J Thromb Haemost 2015 Jun 2
35 28478514 Salidroside Inhibits Inflammation Through PI3K/Akt/HIF Signaling After Focal Cerebral Ischemia in Rats. Inflammation 2017 Aug 1
36 28686686 Protective effect of zinc preconditioning against renal ischemia reperfusion injury is dose dependent. PLoS One 2017 1
37 29400080 Chronic intermittent hypobaric hypoxia provides vascular protection in the aorta of the 2-kidney, 1-clip rat model of hypertension. Can J Physiol Pharmacol 2018 Aug 1
38 30108502 Correction of Anemia in Chronic Kidney Disease With <i>Angelica sinensis</i> Polysaccharide via Restoring EPO Production and Improving Iron Availability. Front Pharmacol 2018 1
39 30344285 Serum and Tissue HIF-2 Alpha Expression in CIN, N-Acetyl Cysteine, and Sildenafil-Treated Rat Models: An Experimental Study. Medicina (Kaunas) 2018 Jul 30 6
40 30669752 [Effect of HIF-2α mediated FoxM1 expression on proliferation of pulmonary artery smooth muscle cells in hypoxic rats]. Zhonghua Yi Xue Za Zhi 2019 Jan 8 1
41 31678498 The effect of oestrogen on mandibular condylar cartilage via hypoxia-inducible factor-2α during osteoarthritis development. Bone 2020 Jan 8
42 32487538 Nonclinical Characterization of the Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat, a Novel Treatment of Anemia of Chronic Kidney Disease. J Pharmacol Exp Ther 2020 Aug 1
43 32736070 Hypoxia-inducible Factor 2α Exerts Neuroprotective Effects by Promoting Angiogenesis via the VEGF/Notch Pathway after Intracerebral Hemorrhage Injury in Rats. Neuroscience 2020 Nov 10 1
44 32860098 Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis. J Mol Med (Berl) 2020 Oct 1
45 33130081 MicroRNA-155-5p/EPAS1/interleukin 6 pathway participated in the protection function of sphingosylphosphorylcholine to ischemic cardiomyocytes. Life Sci 2021 Jan 1 2
46 33219891 Squalene deters drivers of RCC disease progression beyond VHL status. Cell Biol Toxicol 2021 Aug 1
47 33220275 Metformin reduces proteinuria in spontaneously hypertensive rats by activating the HIF-2α-VEGF-A pathway. Eur J Pharmacol 2021 Jan 15 4