Pub. Date : 2021 Jan 15
PMID : 33220275
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin reduces proteinuria in spontaneously hypertensive rats by activating the HIF-2alpha-VEGF-A pathway. | Metformin | endothelial PAS domain protein 1 | Rattus norvegicus |
| 2 | Metformin activated hypoxia-inducible factor-2alpha (Hif-2alpha) in response to VEGF but did not affect Hif-1alpha in rat kidneys and cultured rat podocytes. | Metformin | endothelial PAS domain protein 1 | Rattus norvegicus |
| 3 | Metformin activated hypoxia-inducible factor-2alpha (Hif-2alpha) in response to VEGF but did not affect Hif-1alpha in rat kidneys and cultured rat podocytes. | Metformin | endothelial PAS domain protein 1 | Rattus norvegicus |
| 4 | Metformin reduced the proteinuria induced by long-term high blood pressure in vivo and increased the VEGF-A production in rat kidneys and cultured rat podocytes, probably by activating the Hif-2alpha-VEGF signaling pathway. | Metformin | endothelial PAS domain protein 1 | Rattus norvegicus |