Title : Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation.

Pub. Date : 2003 Aug 22

PMID : 12805361






3 Functional Relationships(s)
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1 NGF treatment did not increase HIF-hydroxylase gene expression or activity, and the reduction of the HIF-2 alpha protein level upon stimulation was observed even in the presence of HIF-hydroxylase inhibitors such as deferoxamine or dimethyloxoglutarate. Deferoxamine endothelial PAS domain protein 1 Rattus norvegicus
2 NGF treatment did not increase HIF-hydroxylase gene expression or activity, and the reduction of the HIF-2 alpha protein level upon stimulation was observed even in the presence of HIF-hydroxylase inhibitors such as deferoxamine or dimethyloxoglutarate. dimethyloxoglutarate endothelial PAS domain protein 1 Rattus norvegicus
3 Hence, in PC12 cells the level of HIF-2 alpha protein and its effect on gene expression can be down-regulated by stimuli other than oxygen. Oxygen endothelial PAS domain protein 1 Rattus norvegicus