Title : Nonclinical Characterization of the Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat, a Novel Treatment of Anemia of Chronic Kidney Disease.

Pub. Date : 2020 Aug

PMID : 32487538






1 Functional Relationships(s)
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1 In cells, roxadustat increased both HIF-1alpha and HIF-2alpha proteins, leading to an increase in EPO production, even in the presence of EPO-suppressing inflammatory cytokines. roxadustat endothelial PAS domain protein 1 Rattus norvegicus