Title : Chronic nicotine induces hypoxia inducible factor-2α in perinatal rat adrenal chromaffin cells: role in transcriptional upregulation of KATP channel subunit Kir6.2.

Pub. Date : 2012 May 15

PMID : 22403787






3 Functional Relationships(s)
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1 Using Western blots, we show that chronic nicotine causes a progressive, time-dependent induction of HIF-2alpha in MAH cells that parallels the upregulation of K(ATP) channel subunit, Kir6.2. Nicotine endothelial PAS domain protein 1 Rattus norvegicus
2 Specificity of this signaling pathway was validated in adrenal glands from pups born to dams exposed to nicotine throughout gestation; the upregulation of both HIF-2alpha and Kir6.2 was confined to medullary, but not cortical, tissue. Nicotine endothelial PAS domain protein 1 Rattus norvegicus
3 This study has uncovered a signaling pathway whereby a nonhypoxic stimulus (nicotine) promotes HIF-2alpha-mediated transcriptional upregulation of a novel target, Kir6.2 subunit. Nicotine endothelial PAS domain protein 1 Rattus norvegicus