| Protein Name | endothelial PAS domain protein 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 29452 |
| Gene Symbol | Epas1 |
| UniProt | Q9JHS1 (EPAS1_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
47
Total Number of Articles : 47 |
Description |
endothelial PAS domain protein 1 |
| Gene Summary |
Enables DNA-binding transcription factor activity and cobalt ion binding activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including norepinephrine biosynthetic process; positive regulation of dopamine biosynthetic process; and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Used to study acute kidney failure and intermittent claudication. Biomarker of artery disease (multiple); bronchopulmonary dysplasia; glucose metabolism disease (multiple); polycystic kidney disease; and renal cell carcinoma. Human ortholog(s) of this gene implicated in familial erythrocytosis 4; lung non-small cell carcinoma; polycythemia; and pulmonary hypertension. Orthologous to human EPAS1 (endothelial PAS domain protein 1). [provided by Alliance of Genome Resources, Jul 2025] |
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