RAS guanyl releasing protein 1 ; Homo sapiens






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1 9582122 RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs. Science 1998 May 15 7
2 9789079 A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Proc Natl Acad Sci U S A 1998 Oct 27 2
3 10777492 Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3. J Biol Chem 2000 Jun 30 5
4 10779365 The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters. Mol Pharmacol 2000 May 14
5 10807788 RasGRP links T-cell receptor signaling to Ras. Blood 2000 May 15 7
6 10913189 Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade. Mol Cell Biol 2000 Aug 1
7 11257115 Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism. J Cell Biol 2001 Mar 19 4
8 11503142 Guanine nucleotide exchange factors CalDAG-GEFI and CalDAG-GEFII are colocalized in striatal projection neurons. J Comp Neurol 2001 Sep 3 11
9 11831896 Structural basis of RasGRP binding to high-affinity PKC ligands. J Med Chem 2002 Feb 14 14
10 11919165 Expression of a catalytically inactive form of diacylglycerol kinase alpha induces sustained signaling through RasGRP. FASEB J 2002 Apr 2
11 12070163 Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta. J Biol Chem 2002 Aug 23 2
12 12091553 ATP-inhibition of M current in frog sympathetic neurons involves phospholipase C but not Ins P(3), Ca(2+), PKC, or Ras. J Neurophysiol 2002 Jul 1
13 12414987 Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters. J Cell Sci 2002 Dec 1 4
14 12730099 Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3. Blood 2003 Aug 15 6
15 14583629 Diacylglycerols containing Omega 3 and Omega 6 fatty acids bind to RasGRP and modulate MAP kinase activation. J Biol Chem 2004 Jan 9 13
16 14702343 Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1. J Biol Chem 2004 Mar 19 2
17 15064353 Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes. Mol Biol Cell 2004 Jun 1
18 15213298 PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters. Mol Pharmacol 2004 Jul 1
19 15319437 Epac- and Ca2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors. J Biol Chem 2004 Nov 5 1
20 15657177 Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells. Blood 2005 May 1 3
21 15899849 A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol Cell Biol 2005 Jun 5
22 15923197 A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha. J Biol Chem 2005 Jul 22 2
23 16042567 Compartmentalized signalling of Ras. Biochem Soc Trans 2005 Aug 2
24 17052215 Regulation of Ras in lymphocytes: get a GRP. Biochem Soc Trans 2006 Nov 3
25 17283063 Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol Cell Biol 2007 Apr 1
26 17486117 The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2. Nat Cell Biol 2007 Jun 3
27 17523924 Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs. Biochem J 2007 Sep 1 5
28 17567957 Regulation of RasGRP1 by B cell antigen receptor requires cooperativity between three domains controlling translocation to the plasma membrane. Mol Biol Cell 2007 Aug 3
29 17658605 SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1. Mol Immunol 2008 Jan 1
30 17702895 Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion. Blood 2007 Nov 15 2
31 17969871 [RasGRP proteins--Ras-activating factors]. Postepy Biochem 2007 1
32 18042941 New insights into the mechanisms of SOS activation. Sci STKE 2007 Nov 27 2
33 18077438 Phorbol ester stimulation of RasGRP1 regulates the sodium-chloride cotransporter by a PKC-independent pathway. Proc Natl Acad Sci U S A 2007 Dec 11 7
34 18160667 A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia. Blood 2008 Mar 1 1
35 18174897 Molecular regulation of T-cell anergy. EMBO Rep 2008 Jan 2
36 18263588 Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta. J Biol Chem 2008 Apr 18 2
37 19100522 A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells. Exp Hematol 2009 Jan 1
38 19168098 Membrane localization of RasGRP1 is controlled by an EF-hand, and by the GEF domain. Biochim Biophys Acta 2009 Mar 2
39 19628710 CalDAG-GEFI is at the nexus of calcium-dependent platelet activation. Blood 2009 Sep 17 3
40 19896467 Functional links between diacylglycerol and phosphatidylinositol signaling systems in human leukocyte-derived cell lines. Biochem Biophys Res Commun 2009 Dec 25 2
41 19933860 RasGRP1 is required for human NK cell function. J Immunol 2009 Dec 15 1
42 20392800 RasGRP1 stimulation enhances ubiquitination and endocytosis of the sodium-chloride cotransporter. Am J Physiol Renal Physiol 2010 Aug 4
43 20413728 Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis. J Leukoc Biol 2010 Aug 4
44 21083522 Farnesyltransferase inhibitors: where are we now? Expert Opin Investig Drugs 2010 Dec 1
45 21138839 Decreased diacylglycerol metabolism enhances ERK activation and augments CD8+ T cell functional responses. J Biol Chem 2011 Feb 18 5
46 21285350 Phosphoinositide 3-kinase regulates plasma membrane targeting of the Ras-specific exchange factor RasGRP1. J Biol Chem 2011 Apr 8 7
47 21673341 Cytotoxicity of farnesyltransferase inhibitors in lymphoid cells mediated by MAPK pathway inhibition and Bim up-regulation. Blood 2011 Nov 3 1
48 21775687 Tight regulation of diacylglycerol-mediated signaling is critical for proper invariant NKT cell development. J Immunol 2011 Sep 1 2
49 21856938 G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1-induced T cell functions. J Immunol 2011 Sep 15 1
50 21966541 Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression. PLoS One 2011 3