Pub. Date : 2000 May
PMID : 10779365
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters. | Diglycerides | RAS guanyl releasing protein 1 | Homo sapiens |
| 2 | The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters. | Phorbol Esters | RAS guanyl releasing protein 1 | Homo sapiens |
| 3 | The phorbol ester [(3)H]phorbol 12, 13-dibutyrate ([(3)H]PDBu) bound to this C1 domain (C1-RasGRP) with a dissociation constant of 0.58 +/- 0.08 nM, similar to that observed previously for PKC. | Phorbol Esters | RAS guanyl releasing protein 1 | Homo sapiens |
| 4 | The phorbol ester [(3)H]phorbol 12, 13-dibutyrate ([(3)H]PDBu) bound to this C1 domain (C1-RasGRP) with a dissociation constant of 0.58 +/- 0.08 nM, similar to that observed previously for PKC. | [(3)h]phorbol 12, 13-dibutyrate | RAS guanyl releasing protein 1 | Homo sapiens |
| 5 | The phorbol ester [(3)H]phorbol 12, 13-dibutyrate ([(3)H]PDBu) bound to this C1 domain (C1-RasGRP) with a dissociation constant of 0.58 +/- 0.08 nM, similar to that observed previously for PKC. | Tritium | RAS guanyl releasing protein 1 | Homo sapiens |
| 6 | The phorbol ester [(3)H]phorbol 12, 13-dibutyrate ([(3)H]PDBu) bound to this C1 domain (C1-RasGRP) with a dissociation constant of 0.58 +/- 0.08 nM, similar to that observed previously for PKC. | Phorbol 12,13-Dibutyrate | RAS guanyl releasing protein 1 | Homo sapiens |
| 7 | Likewise, the potent PKC activator bryostatin 1, a compound currently in clinical trials, showed high affinity binding for C1-RasGRP. | bryostatin 1 | RAS guanyl releasing protein 1 | Homo sapiens |
| 8 | The C1 domain plus the EF-hand motif of RasGRP (C1EF-RasGRP) was markedly less dependent on acidic phospholipids than was PKCalpha. | Phospholipids | RAS guanyl releasing protein 1 | Homo sapiens |
| 9 | The C1 domain plus the EF-hand motif of RasGRP (C1EF-RasGRP) was markedly less dependent on acidic phospholipids than was PKCalpha. | Phospholipids | RAS guanyl releasing protein 1 | Homo sapiens |
| 10 | We conclude that RasGRP is a high affinity receptor for phorbol esters and diacylglycerol. | Phorbol Esters | RAS guanyl releasing protein 1 | Homo sapiens |
| 11 | We conclude that RasGRP is a high affinity receptor for phorbol esters and diacylglycerol. | Diglycerides | RAS guanyl releasing protein 1 | Homo sapiens |
| 12 | RasGRP thus provides a direct link between diacylglycerol generation or phorbol ester/bryostatin treatment and Ras activation. | Diglycerides | RAS guanyl releasing protein 1 | Homo sapiens |
| 13 | RasGRP thus provides a direct link between diacylglycerol generation or phorbol ester/bryostatin treatment and Ras activation. | Phorbol Esters | RAS guanyl releasing protein 1 | Homo sapiens |
| 14 | RasGRP thus provides a direct link between diacylglycerol generation or phorbol ester/bryostatin treatment and Ras activation. | Bryostatins | RAS guanyl releasing protein 1 | Homo sapiens |