Title : Regulation of RasGRP1 by B cell antigen receptor requires cooperativity between three domains controlling translocation to the plasma membrane.

Pub. Date : 2007 Aug

PMID : 17567957






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 RasGRP1 contains a diacylglycerol-binding C1 domain, and it has been assumed that this domain is entirely responsible for RasGRP1 translocation. Diglycerides RAS guanyl releasing protein 1 Homo sapiens
2 RasGRP1 contains a diacylglycerol-binding C1 domain, and it has been assumed that this domain is entirely responsible for RasGRP1 translocation. Diglycerides RAS guanyl releasing protein 1 Homo sapiens
3 By binding to diacylglycerol generated by BCR-coupled phospholipase Cgamma2, the C1 domain counteracts the SuPT domain and enables efficient RasGRP1 translocation to the plasma membrane. Diglycerides RAS guanyl releasing protein 1 Homo sapiens