Pub. Date : 2005 Jun
PMID : 15899849
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In T lymphocytes, Ras can be activated by two Ras exchange factors, SOS and RasGRP1, which are recruited through the adapters Grb2 and LAT and via the second-messenger diacylglycerol (DAG), respectively. | Diglycerides | RAS guanyl releasing protein 1 | Homo sapiens |
| 2 | In T lymphocytes, Ras can be activated by two Ras exchange factors, SOS and RasGRP1, which are recruited through the adapters Grb2 and LAT and via the second-messenger diacylglycerol (DAG), respectively. | Diglycerides | RAS guanyl releasing protein 1 | Homo sapiens |
| 3 | RasGRP1 relies on its DAG-binding domain to selectively activate Erk kinases. | Diglycerides | RAS guanyl releasing protein 1 | Homo sapiens |
| 4 | Activation of Erk correlates with the phosphorylation of threonine residue 184 in RasGRP1. | Threonine | RAS guanyl releasing protein 1 | Homo sapiens |
| 5 | Last, DAG-PKC-RasGRP1-driven Ras-Erk activation in T cells is a unique signaling event, not simply compensated for by SOS activity. | Diglycerides | RAS guanyl releasing protein 1 | Homo sapiens |