| Protein Name | RAS guanyl releasing protein 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 10125 |
| Gene Symbol | RASGRP1 |
| UniProt | O95267 (GRP1_HUMAN), B2RA89 (B2RA89_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
62
Total Number of Articles : 80 |
Description |
RAS guanyl releasing protein 1 |
| Gene Summary |
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008] |
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