Pub. Date : 2001 Mar 19
PMID : 11257115
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Coimmunoprecipitation of DGK zeta and RasGRP was enhanced in the presence of phorbol esters, which are DAG analogues that cannot be metabolized by DGKs, suggesting that DAG signaling can induce their interaction. | Phorbol Esters | RAS guanyl releasing protein 1 | Homo sapiens |
| 2 | Coimmunoprecipitation of DGK zeta and RasGRP was enhanced in the presence of phorbol esters, which are DAG analogues that cannot be metabolized by DGKs, suggesting that DAG signaling can induce their interaction. | Diglycerides | RAS guanyl releasing protein 1 | Homo sapiens |
| 3 | Coimmunoprecipitation of DGK zeta and RasGRP was enhanced in the presence of phorbol esters, which are DAG analogues that cannot be metabolized by DGKs, suggesting that DAG signaling can induce their interaction. | Diglycerides | RAS guanyl releasing protein 1 | Homo sapiens |
| 4 | Thus, we have identified a novel way to regulate Ras activation: through DGK zeta, which controls local accumulation of DAG that would otherwise activate RasGRP. | Diglycerides | RAS guanyl releasing protein 1 | Homo sapiens |