egl-9 family hypoxia-inducible factor 2 ; Mus musculus






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1 16785028 Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: prolyl hydroxylases tune the biological normoxic set point. Free Radic Biol Med 2006 Jun 15 4
2 17646578 Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation 2007 Aug 14 1
3 18176562 Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet 2008 Feb 6
4 18316022 Muscle fatigue from losing your PHD. Cell Metab 2008 Mar 1
5 19546390 Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization. Circulation 2009 Jul 7 1
6 19818783 Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury. Gastroenterology 2010 Mar 3
7 20010896 Diabetic nephropathy: a disorder of oxygen metabolism? Nat Rev Nephrol 2010 Feb 2
8 21083501 Disruption of hypoxia-inducible transcription factor-prolyl hydroxylase domain-1 (PHD-1-/-) attenuates ex vivo myocardial ischemia/reperfusion injury through hypoxia-inducible factor-1α transcription factor and its target genes in mice. Antioxid Redox Signal 2011 Oct 1 2
9 21228376 A novel specific application of pyruvate protects the mouse retina against white light damage: differential stabilization of HIF-1α and HIF-2α. Invest Ophthalmol Vis Sci 2011 May 11 2
10 21704147 Impaired hypoxic response in senescent mouse brain. Int J Dev Neurosci 2011 Oct 1
11 22313584 Effect of conjugated linoleic acid on inhibition of prolyl hydroxylase 1 in hearts of mice. Lipids Health Dis 2012 Feb 7 9
12 22961008 Deficiency of the oxygen sensor PHD1 augments liver regeneration after partial hepatectomy. Langenbecks Arch Surg 2012 Dec 2
13 23319629 Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance. Proc Natl Acad Sci U S A 2013 Jan 29 1
14 23690557 Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2. J Physiol 2013 Jul 15 1
15 23978105 Targeted gene deletion of prolyl hydroxylase domain protein 3 triggers angiogenesis and preserves cardiac function by stabilizing hypoxia inducible factor 1 alpha following myocardial infarction. Curr Pharm Des 2014 1
16 24338020 The role of prolyl hydroxylase domain protein (PHD) during rosiglitazone-induced adipocyte differentiation. J Biol Chem 2014 Jan 31 1
17 25675298 Prolyl hydroxylase regulates axonal rewiring and motor recovery after traumatic brain injury. Cell Death Dis 2015 Feb 12 2
18 25846796 Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin. Genes Dev 2015 Apr 15 1
19 26290450 PHD1 regulates p53-mediated colorectal cancer chemoresistance. EMBO Mol Med 2015 Oct 1
20 26774962 Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism. Cell Metab 2016 Feb 9 8
21 27088801 Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin. J Clin Invest 2016 May 2 1
22 27094951 Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice. Sci Rep 2016 Apr 20 2
23 27125949 Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia. Eur Heart J 2016 Oct 14 5
24 27148687 Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell Death Dis 2016 May 5 1
25 27800509 Hyperplasia and hypertrophy of pulmonary neuroepithelial bodies, presumed airway hypoxia sensors, in hypoxia-inducible factor prolyl hydroxylase-deficient mice. Hypoxia (Auckl) 2016 1
26 27981571 Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis. J Pathol 2017 Mar 3
27 28036276 EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor. Oncotarget 2017 Jan 24 2
28 28266966 Prolyl Hydroxylase Inhibition Enhances Liver Regeneration Without Induction of Tumor Growth. Ann Surg 2017 Apr 1
29 28333714 Novel regulators of plasma lipid levels. Curr Opin Lipidol 2017 Jun 1
30 29500923 Regulation of hypoxia inducible factor/prolyl hydroxylase binding domain proteins 1 by PPARα and high salt diet. J Basic Clin Physiol Pharmacol 2018 Mar 28 4
31 29899699 Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice. Front Pharmacol 2018 1
32 30248340 Loss of Prolyl-Hydroxylase 1 Protects against Biliary Fibrosis via Attenuated Activation of Hepatic Stellate Cells. Am J Pathol 2018 Dec 2
33 31029587 Null mutation in P4h-tm leads to decreased fear and anxiety and increased social behavior in mice. Neuropharmacology 2019 Jul 15 1
34 31924757 PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase. Nat Commun 2020 Jan 10 3
35 31996410 Inhibition of Endothelial PHD2 Suppresses Post-Ischemic Kidney Inflammation through Hypoxia-Inducible Factor-1. J Am Soc Nephrol 2020 Mar 1
36 32814068 Systemic hypoxia mimicry enhances axonal regeneration and functional recovery following peripheral nerve injury. Exp Neurol 2020 Dec 1
37 33792566 Hypoxia-inducible factor-1α-dependent induction of miR122 enhances hepatic ischemia tolerance. J Clin Invest 2021 Apr 1 2
38 34571764 Long-Term Environmental Hypoxia Exposure and Haematopoietic Prolyl Hydroxylase-1 Deletion Do Not Impact Experimental Crohn's Like Ileitis. Biology (Basel) 2021 Sep 8 1