Pub. Date : 2016 Oct 14
PMID : 27125949
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS AND RESULTS: Mice deficient for oxygen sensor HIF-prolyl hydroxylase 1 (PHD1) were backcrossed onto an atherogenic low-density lipoprotein receptor (LDLR) knockout background and atherosclerosis was studied upon 8 weeks of western-type diet. | Oxygen | egl-9 family hypoxia-inducible factor 2 | Mus musculus |
| 2 | PHD1-/-LDLR-/- mice presented a sharp reduction in VLDL and LDL plasma cholesterol levels. | Cholesterol | egl-9 family hypoxia-inducible factor 2 | Mus musculus |
| 3 | Mechanistically, cholesterol-lowering in PHD1 deficient mice was a result of enhanced cholesterol excretion from blood to intestines and ultimately faeces. | Cholesterol | egl-9 family hypoxia-inducible factor 2 | Mus musculus |
| 4 | Mechanistically, cholesterol-lowering in PHD1 deficient mice was a result of enhanced cholesterol excretion from blood to intestines and ultimately faeces. | Cholesterol | egl-9 family hypoxia-inducible factor 2 | Mus musculus |
| 5 | In addition, when studying PHD1-/- in diet-induced obesity (14 weeks high-fat diet) mice were less glucose intolerant when compared with WT littermate controls. | Glucose | egl-9 family hypoxia-inducible factor 2 | Mus musculus |