Title : Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: prolyl hydroxylases tune the biological normoxic set point.

Pub. Date : 2006 Jun 15

PMID : 16785028






4 Functional Relationships(s)
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Protein Name
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1 When grown under high O(2) conditions, cells reset their normoxic set point upward by down-regulating the expression of PHD1-3. Oxygen egl-9 family hypoxia-inducible factor 2 Mus musculus
2 When grown under low O(2) conditions, cells reset their normoxic set point downward by inducing the expression of PHD1-3. Oxygen egl-9 family hypoxia-inducible factor 2 Mus musculus
3 Exposure of mice to a hyperoxic 50% O(2) ambience repressed the expression of PHD1-3, indicating that O(2)-sensitive regulation of PHD expression is effective in the brain in vivo. Oxygen egl-9 family hypoxia-inducible factor 2 Mus musculus
4 Exposure of mice to a hyperoxic 50% O(2) ambience repressed the expression of PHD1-3, indicating that O(2)-sensitive regulation of PHD expression is effective in the brain in vivo. Oxygen egl-9 family hypoxia-inducible factor 2 Mus musculus