Pub. Date : 2012 Feb 7
PMID : 22313584
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of conjugated linoleic acid on inhibition of prolyl hydroxylase 1 in hearts of mice. | Linoleic Acid | egl-9 family hypoxia-inducible factor 2 | Mus musculus |
| 2 | But the inhibition of prolyl hydroxylase 1 (PHD1) associated with induction of hypoxia inducible factors (HIFs) by CLA in these protective effects has never been reported before. | cis-9, trans-11-conjugated linoleic acid | egl-9 family hypoxia-inducible factor 2 | Mus musculus |
| 3 | But the inhibition of prolyl hydroxylase 1 (PHD1) associated with induction of hypoxia inducible factors (HIFs) by CLA in these protective effects has never been reported before. | cis-9, trans-11-conjugated linoleic acid | egl-9 family hypoxia-inducible factor 2 | Mus musculus |
| 4 | The objective of this study was to evaluate if the two predominant cis-9,trans-11 (c9, t11), trans-10,cis-12 (t10, c12) CLA isomers and mixture of these two isomers can inhibit PHD1 with induction of HIFs in myocardium in mice and subsequent effects on myocardium metabolism. | 9,11-linoleic acid | egl-9 family hypoxia-inducible factor 2 | Mus musculus |
| 5 | The objective of this study was to evaluate if the two predominant cis-9,trans-11 (c9, t11), trans-10,cis-12 (t10, c12) CLA isomers and mixture of these two isomers can inhibit PHD1 with induction of HIFs in myocardium in mice and subsequent effects on myocardium metabolism. | trans-10,cis-12 | egl-9 family hypoxia-inducible factor 2 | Mus musculus |
| 6 | The objective of this study was to evaluate if the two predominant cis-9,trans-11 (c9, t11), trans-10,cis-12 (t10, c12) CLA isomers and mixture of these two isomers can inhibit PHD1 with induction of HIFs in myocardium in mice and subsequent effects on myocardium metabolism. | cis-9, trans-11-conjugated linoleic acid | egl-9 family hypoxia-inducible factor 2 | Mus musculus |
| 7 | RESULTS: CLA mixture and c9, t11 CLA inhibited PHD1 protein expression and increased the levels of protein and mRNA in HIF-2alpha in myocardium in mice. | cis-9, trans-11-conjugated linoleic acid | egl-9 family hypoxia-inducible factor 2 | Mus musculus |
| 8 | RESULTS: CLA mixture and c9, t11 CLA inhibited PHD1 protein expression and increased the levels of protein and mRNA in HIF-2alpha in myocardium in mice. | cis-9, trans-11-conjugated linoleic acid | egl-9 family hypoxia-inducible factor 2 | Mus musculus |
| 9 | CONCLUSION: CLA mixture and c9, t11 CLA could inhibit PHD1 and induce HIF-2alpha in myocardium in mice, which is associated with upregulation of PDK4 by activation of PPARalpha. | cis-9, trans-11-conjugated linoleic acid | egl-9 family hypoxia-inducible factor 2 | Mus musculus |