Title : A novel specific application of pyruvate protects the mouse retina against white light damage: differential stabilization of HIF-1α and HIF-2α.

Pub. Date : 2011 May 11

PMID : 21228376






2 Functional Relationships(s)
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1 In the retinal explant system, addition or depletion of pyruvate caused only changes of HIF-1alpha and prolyl hydroxylase (PHD)-2, while HIF-2alpha and PHD1 were not affected. Pyruvic Acid egl-9 family hypoxia-inducible factor 2 Mus musculus
2 This differential stabilization might be related to the distinct preference of their degrading enzyme of PHD2 and PHD1 in response to pyruvate treatment. Pyruvic Acid egl-9 family hypoxia-inducible factor 2 Mus musculus