peptidylprolyl isomerase A ; Homo sapiens






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1 1338979 Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition. Protein Sci 1992 Sep 1
2 1453463 Similarities and differences between human cyclophilin A and other beta-barrel structures. Structural refinement at 1.63 A resolution. J Mol Biol 1992 Nov 20 3
3 7529414 The chemistry of signal transduction. Proc Natl Acad Sci U S A 1995 Jan 3 4
4 7541038 Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity. J Biol Chem 1995 Jun 23 2
5 7590732 Cyclophilin A, the major intracellular receptor for the immunosuppressant cyclosporin A, maps to chromosome 7p11.2-p13: four pseudogenes map to chromosomes 3, 10, 14, and 18. Genomics 1995 Jul 1 5
6 7650689 The role of water molecules in the structure-based design of (5-hydroxynorvaline)-2-cyclosporin: synthesis, biological activity, and crystallographic analysis with cyclophilin A. J Med Chem 1995 Aug 18 5
7 7829860 Selective assay for CyPA and CyPB in human blood using highly specific anti-peptide antibodies. J Immunol Methods 1995 Jan 13 2
8 7866747 Conformational polymorphism of cyclosporin A. Structure 1994 Oct 15 1
9 7990129 The molecular replacement solution and X-ray refinement to 2.8 A of a decameric complex of human cyclophilin A with the immunosuppressive drug cyclosporin A. J Mol Biol 1994 Dec 9 1
10 8031755 Human cyclophilin C: primary structure, tissue distribution, and determination of binding specificity for cyclosporins. Biochemistry 1994 Jul 12 3
11 8073029 The X-ray structure of (MeBm2t)1-cyclosporin complexed with cyclophilin A provides an explanation for its anomalously high immunosuppressive activity. Protein Eng 1994 May 1
12 8075981 Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A. Structure 1994 Jan 15 9
13 8197205 X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain. Proc Natl Acad Sci U S A 1994 May 24 3
14 8335079 Interleukin-8 is a cyclosporin A binding protein. Experientia 1993 Jul 5 1
15 8421501 X-ray structure of a decameric cyclophilin-cyclosporin crystal complex. Nature 1993 Jan 7 3
16 8513493 Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B. Cell 1993 Jun 18 1
17 8518284 Secondary structure and backbone resonance assignments of the periplasmic cyclophilin type peptidyl-prolyl isomerase from Escherichia coli. Biochemistry 1993 Jun 29 1
18 8554896 Analysis and localization of cyclophilin A found in the virions of human immunodeficiency virus type 1 MN strain. AIDS Res Hum Retroviruses 1995 Sep 2
19 8601841 The substrate-binding site in Escherichia coli cyclophilin A preferably recognizes a cis-proline isomer or a highly distorted form of the trans isomer. J Mol Biol 1996 Mar 15 8
20 9016720 Cyclophilin A complexed with a fragment of HIV-1 gag protein: insights into HIV-1 infectious activity. Structure 1997 Jan 15 8
21 9032343 The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyprotein. J Virol 1997 Mar 4
22 9043670 Conformational control of cyclosporin through substitution of the N-5 position. A new class of cyclosporin antagonists. Bioorg Med Chem 1997 Jan 3
23 9223641 Molecular recognition in the HIV-1 capsid/cyclophilin A complex. J Mol Biol 1997 Jun 27 4
24 9261419 Cyclophilin A-induced alterations of human immunodeficiency virus type 1 CA protein in vitro. J Virol 1997 Sep 4
25 9261445 Active-site residues of cyclophilin A are crucial for its incorporation into human immunodeficiency virus type 1 virions. J Virol 1997 Sep 7
26 9299338 The NMR solution conformation of unligated human cyclophilin A. J Mol Biol 1997 Sep 12 5
27 9305737 HIV protease substrate conformation: modulation by cyclophilin A. FEBS Lett 1997 Sep 1 2
28 9380739 Transfer of the HIV-1 cyclophilin-binding site to simian immunodeficiency virus from Macaca mulatta can confer both cyclosporin sensitivity and cyclosporin dependence. Proc Natl Acad Sci U S A 1997 Sep 30 6
29 9385632 Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein. Protein Sci 1997 Nov 16
30 9636359 Cyclophilin a modulates processing of human immunodeficiency virus type 1 p55Gag: mechanism for antiviral effects of cyclosporin A. Virology 1998 Jun 5 2
31 9675023 Competitive and slow-binding inhibition of calcineurin by drug x immunophilin complexes. Arch Biochem Biophys 1998 Jul 15 8
32 9705263 Mechanistic independence of Nef and cyclophilin A enhancement of human immunodeficiency virus type 1 infectivity. Virology 1998 Aug 15 6
33 9826540 Modulation of MDR1 and CYP3A expression by dexamethasone: evidence for an inverse regulation in adrenals. Biochem Biophys Res Commun 1998 Nov 18 1
34 10026140 Maturation-induced conformational changes of HIV-1 capsid protein and identification of two high affinity sites for cyclophilins in the C-terminal domain. J Biol Chem 1999 Feb 26 6
35 10208939 Cyclophilin A incorporation is not required for human immunodeficiency virus type 1 particle maturation and does not destabilize the mature capsid. Virology 1999 Apr 25 2
36 10382674 Tryptophan microstate reshuffling upon the binding of cyclosporin A to human cyclophilin A. Proteins 1999 Jun 1 1
37 10441120 Backbone dynamics of the N-terminal domain of the HIV-1 capsid protein and comparison with the G94D mutant conferring cyclosporin resistance/dependence. Biochemistry 1999 Aug 10 2
38 10581250 Host cyclophilin A mediates HIV-1 attachment to target cells via heparans. EMBO J 1999 Dec 1 5
39 10756109 The three-dimensional structure of a Plasmodium falciparum cyclophilin in complex with the potent anti-malarial cyclosporin A. J Mol Biol 2000 Apr 21 1
40 10852119 Human immunodeficiency virus type 1 hijacks host cyclophilin A for its attachment to target cells. Immunol Res 2000 2
41 11055983 Cyclophilin A is a secreted growth factor induced by oxidative stress. Circ Res 2000 Oct 27 6
42 11206060 Delineation of the calcineurin-interacting region of cyclophilin B. Protein Sci 2000 Dec 2
43 11312344 Structural consequences of cyclophilin A binding on maturational refolding in human immunodeficiency virus type 1 capsid protein. J Virol 2001 May 5
44 11390385 Cyclophilin a binds to peroxiredoxins and activates its peroxidase activity. J Biol Chem 2001 Aug 10 6
45 11390463 Sanglifehrin A, a novel cyclophilin-binding compound showing immunosuppressive activity with a new mechanism of action. J Immunol 2001 Jun 15 5
46 11836403 trans-Complementation rescue of cyclophilin A-deficient viruses reveals that the requirement for cyclophilin A in human immunodeficiency virus type 1 replication is independent of its isomerase activity. J Virol 2002 Mar 4
47 11929983 Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A. Proc Natl Acad Sci U S A 2002 Apr 16 5
48 11943775 Active site residues of cyclophilin A are crucial for its signaling activity via CD147. J Biol Chem 2002 Jun 21 4
49 12009870 Differential dependence of the infectivity of HIV-1 group O isolates on the cellular protein cyclophilin A. Virology 2002 Mar 15 3
50 12181673 Immunophilins and HIV-1 infection. Arch Virol 2002 Aug 1