Pub. Date : 1997 Jan 15
PMID : 9016720
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: Cyclophilin A (CyPA), a receptor of the immunosuppressive drug cyclosporin A, catalyzes the cis-trans isomerization of peptidyl-prolyl bonds and is required for the infectious activity of human immunodeficiency virus type 1 (HIV-1). | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |
| 2 | Two residues of the 25-mer (Pro90-Ile91) bind to CyPA in a similar manner to two residues (Pro-Phe) of the CyPA substrate, succinyl-Ala-Ala-Pro-Phe-p-nitroanilide (AAPF). | H-Pro-Phe-OH | peptidylprolyl isomerase A | Homo sapiens |
| 3 | Two residues of the 25-mer (Pro90-Ile91) bind to CyPA in a similar manner to two residues (Pro-Phe) of the CyPA substrate, succinyl-Ala-Ala-Pro-Phe-p-nitroanilide (AAPF). | H-Pro-Phe-OH | peptidylprolyl isomerase A | Homo sapiens |
| 4 | Two residues of the 25-mer (Pro90-Ile91) bind to CyPA in a similar manner to two residues (Pro-Phe) of the CyPA substrate, succinyl-Ala-Ala-Pro-Phe-p-nitroanilide (AAPF). | succinyl-alanyl-alanyl-prolyl-phenylalanine-4-nitroanilide | peptidylprolyl isomerase A | Homo sapiens |
| 5 | Two residues of the 25-mer (Pro90-Ile91) bind to CyPA in a similar manner to two residues (Pro-Phe) of the CyPA substrate, succinyl-Ala-Ala-Pro-Phe-p-nitroanilide (AAPF). | succinyl-alanyl-alanyl-prolyl-phenylalanine-4-nitroanilide | peptidylprolyl isomerase A | Homo sapiens |
| 6 | Two residues of the 25-mer (Pro90-Ile91) bind to CyPA in a similar manner to two residues (Pro-Phe) of the CyPA substrate, succinyl-Ala-Ala-Pro-Phe-p-nitroanilide (AAPF). | AAPF | peptidylprolyl isomerase A | Homo sapiens |
| 7 | Two residues of the 25-mer (Pro90-Ile91) bind to CyPA in a similar manner to two residues (Pro-Phe) of the CyPA substrate, succinyl-Ala-Ala-Pro-Phe-p-nitroanilide (AAPF). | AAPF | peptidylprolyl isomerase A | Homo sapiens |
| 8 | CONCLUSIONS: The unfavorable backbone conformation of Gly89 of the gag 25-mer fragment suggests that binding between HIV-1 gag protein and CyPA requires a special sequence, Gly-Pro. | glycylproline | peptidylprolyl isomerase A | Homo sapiens |