Protein Name peptidylprolyl isomerase A
Organism Homo sapiens
Gene ID 5478
Gene Symbol

PPIA

UniProt P62937 (PPIA_HUMAN), V9HWF5 (V9HWF5_HUMAN)
Relationships Total Number of functionally related compound(s) : 195
Total Number of Articles : 294
Description

peptidylprolyl isomerase A

Gene Summary

This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

synonyms
  • peptidyl-prolyl cis-trans isomerase A
  • PPIase A
  • T cell cyclophilin
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Properties