Title : Conformational control of cyclosporin through substitution of the N-5 position. A new class of cyclosporin antagonists.

Pub. Date : 1997 Jan

PMID : 9043670






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 These are devoid of immunosuppressive activity in vitro but they have binding affinity for cyclophilin A (CypA) similar to that of CsA and thus represent a new class of cyclosporin antagonists. Cyclosporine peptidylprolyl isomerase A Homo sapiens
2 These are devoid of immunosuppressive activity in vitro but they have binding affinity for cyclophilin A (CypA) similar to that of CsA and thus represent a new class of cyclosporin antagonists. Cyclosporine peptidylprolyl isomerase A Homo sapiens
3 A comparison of this NMR data with X-ray crystallographic analysis of a CypA/CsA derivative complex demonstrates that the solution structure does not correspond to the bioactive conformation. Cyclosporine peptidylprolyl isomerase A Homo sapiens