proprotein convertase subtilisin/kexin type 6 ; Homo sapiens






42 Article(s)
Download
PMID
Title
Journal
Pub. Date
#Total Relationship(s)
1 1741956 Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15. DNA Cell Biol 1991 Dec 2
2 8179631 Identification of novel cDNAs encoding human kexin-like protease, PACE4 isoforms. Biochem Biophys Res Commun 1994 Apr 29 1
3 8218226 PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE. Biochemistry 1993 Nov 2 2
4 8262218 Proprotein processing activity and cleavage site selectivity of the Kex2-like endoprotease PACE4. FEBS Lett 1993 Dec 20 1
5 8468318 Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4. J Biochem 1993 Feb 1
6 8906861 Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform. FEBS Lett 1996 Oct 28 1
7 9032441 PACE4: a subtilisin-like endoprotease with unique properties. Biochem J 1997 Feb 1 7
8 9378725 Genomic organization and alternative splicing of human PACE4 (SPC4), kexin-like processing endoprotease. J Biochem 1997 Aug 1
9 9738469 Biosynthetic processing and quaternary interactions of proprotein convertase SPC4 (PACE4). FEBS Lett 1998 Aug 28 5
10 11917148 Development of selectivity of alpha1-antitrypsin variant by mutagenesis in its reactive site loop against proprotein convertase. A crucial role of the P4 arginine in PACE4 inhibition. Protein Eng 2002 Feb 2
11 12097169 The proprotein convertase PACE4 is upregulated by PDGF-BB in megakaryocytes: gene expression of PACE4 and furin is regulated differently in Dami cells. J Biochem 2002 Jul 4
12 12535616 Secretory proprotein convertases PACE4 and PC6A are heparin-binding proteins which are localized in the extracellular matrix. Potential role of PACE4 in the activation of proproteins in the extracellular matrix. Biochim Biophys Acta 2003 Jan 31 3
13 12805404 Epigenetic regulation of proprotein convertase PACE4 gene expression in human ovarian cancer cells. Mol Cancer Res 2003 Jun 4
14 16289022 ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms. Arch Biochem Biophys 2005 Dec 1 2
15 17351018 Engineering of alpha1-antitrypsin variants selective for subtilisin-like proprotein convertases PACE4 and PC6: importance of the P2' residue in stable complex formation of the serpin with proprotein convertase. Protein Eng Des Sel 2007 Apr 3
16 17351764 The proprotein convertases are potential targets in the treatment of dyslipidemia. J Mol Med (Berl) 2007 Jul 1
17 17391681 A high performance liquid chromatography assay for monitoring proprotein convertase activity. J Chromatogr A 2007 Apr 27 2
18 17707572 Use of RAPD to detect sodium arsenite-induced DNA damage in human lymphoblastoid cells. Toxicology 2007 Sep 24 2
19 18343183 The activation and physiological functions of the proprotein convertases. Int J Biochem Cell Biol 2008 2
20 22679642 The biology and therapeutic targeting of the proprotein convertases. Nat Rev Drug Discov 2012 May 2
21 24350995 Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J Med Chem 2014 Jan 9 1
22 25220591 PACE4-based molecular targeting of prostate cancer using an engineered ⁶⁴Cu-radiolabeled peptide inhibitor. Neoplasia 2014 Aug 1
23 25889349 CdSe quantum dot-functionalized TiO2 nanohybrids as a visible light induced photoelectrochemical platform for the detection of proprotein convertase subtilisin/kexin type 6. Biosens Bioelectron 2015 Sep 15 6
24 26119758 A visible light induced photoelectrochemical aptsensor constructed by aligned ZnO@CdTe core shell nanocable arrays/carboxylated g-C3N4 for the detection of Proprotein convertase subtilisin/kexin type 6 gene. Biosens Bioelectron 2015 Dec 15 2
25 26259032 PCSK6-mediated corin activation is essential for normal blood pressure. Nat Med 2015 Sep 1
26 26283733 Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder. Mol Cell Biol 2015 Nov 1
27 26341526 PACE4 (PCSK6): another proprotein convertase link to iron homeostasis? Haematologica 2015 Sep 2
28 26341529 Comment on: PACE4 (PCSK6): another proprotein convertase linked to iron homeostasis? Haematologica 2015 Sep 2
29 26604689 PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways. Drug Des Devel Ther 2015 4
30 27126696 Enhanced Proteolytic Processing of Recombinant Human Coagulation Factor VIII B-Domain Variants by Recombinant Furins. Mol Biotechnol 2016 Jun 1
31 28287731 Positional Scanning Identifies the Molecular Determinants of a High Affinity Multi-Leucine Inhibitor for Furin and PACE4. J Med Chem 2017 Apr 13 1
32 28483279 Macrocyclization of a potent PACE4 inhibitor: Benefits and limitations. Eur J Cell Biol 2017 Aug 5
33 28722823 Rational Design of a Highly Potent and Selective Peptide Inhibitor of PACE4 by Salt Bridge Interaction with D160 at Position P3. ChemMedChem 2017 Aug 8 5
34 28985241 Short-Term High-Salt Diet Increases Corin Level to Regulate the Salt-Water Balance in Humans and Rodents. Am J Hypertens 2018 Jan 12 4
35 30180568 Increasing C-Terminal Hydrophobicity Improves the Cell Permeability and Antiproliferative Activity of PACE4 Inhibitors against Prostate Cancer Cell Lines. J Med Chem 2018 Sep 27 2
36 30501188 Improving the Selectivity of PACE4 Inhibitors through Modifications of the P1 Residue. J Med Chem 2018 Dec 27 7
37 32449780 Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma. Acta Derm Venereol 2020 May 28 2
38 33359561 Up-regulation of PCSK6 by lipid oxidation products: A possible role in atherosclerosis. Biochimie 2021 Feb 7
39 33382413 Mouse Models of Human Proprotein Convertase Insufficiency. Endocr Rev 2021 May 25 1
40 33938057 Bio-inspired and Eco-friendly Synthesis of 3D Spongy Meso-Microporous Carbons from CO<sub>2</sub> for Supercapacitors. Chemistry 2021 Jul 16 2
41 34202098 How Do Enveloped Viruses Exploit the Secretory Proprotein Convertases to Regulate Infectivity and Spread? Viruses 2021 Jun 25 1
42 34301174 Up-regulation of microRNA-135 or silencing of PCSK6 attenuates inflammatory response in preeclampsia by restricting NLRP3 inflammasome. Mol Med 2021 Jul 23 2