Title : Rational Design of a Highly Potent and Selective Peptide Inhibitor of PACE4 by Salt Bridge Interaction with D160 at Position P3.

Pub. Date : 2017 Aug 8

PMID : 28722823






5 Functional Relationships(s)
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1 Rational Design of a Highly Potent and Selective Peptide Inhibitor of PACE4 by Salt Bridge Interaction with D160 at Position P3. d160 proprotein convertase subtilisin/kexin type 6 Homo sapiens
2 In seeking for modifications to increase the selectivity of this ligand toward PACE4, we replaced one of its P3 Val methyl groups with a basic group capable of forming a salt bridge with D160 of PACE4. Valine proprotein convertase subtilisin/kexin type 6 Homo sapiens
3 In seeking for modifications to increase the selectivity of this ligand toward PACE4, we replaced one of its P3 Val methyl groups with a basic group capable of forming a salt bridge with D160 of PACE4. Valine proprotein convertase subtilisin/kexin type 6 Homo sapiens
4 In seeking for modifications to increase the selectivity of this ligand toward PACE4, we replaced one of its P3 Val methyl groups with a basic group capable of forming a salt bridge with D160 of PACE4. d160 proprotein convertase subtilisin/kexin type 6 Homo sapiens
5 In seeking for modifications to increase the selectivity of this ligand toward PACE4, we replaced one of its P3 Val methyl groups with a basic group capable of forming a salt bridge with D160 of PACE4. d160 proprotein convertase subtilisin/kexin type 6 Homo sapiens