Pub. Date : 2021 Feb
PMID : 33359561
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In U937 promonocytic cells and in human umbilical vein endothelial cells, an oxysterol mixture and HNE were able to up-regulate the level and activity of PCSK6, resulting in MMP-9 activation as demonstrated by PCSK6 silencing. | Oxysterols | proprotein convertase subtilisin/kexin type 6 | Homo sapiens |
| 2 | In U937 promonocytic cells and in human umbilical vein endothelial cells, an oxysterol mixture and HNE were able to up-regulate the level and activity of PCSK6, resulting in MMP-9 activation as demonstrated by PCSK6 silencing. | Oxysterols | proprotein convertase subtilisin/kexin type 6 | Homo sapiens |
| 3 | Inflammation, enhanced by these lipid oxidation products, plays a key role in the up-regulation of PCSK6 activity as demonstrated by cell pretreatment with NS-398, with epigallocatechin gallate or with acetylsalicylic acid, all with anti-inflammatory effects. | N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide | proprotein convertase subtilisin/kexin type 6 | Homo sapiens |
| 4 | Inflammation, enhanced by these lipid oxidation products, plays a key role in the up-regulation of PCSK6 activity as demonstrated by cell pretreatment with NS-398, with epigallocatechin gallate or with acetylsalicylic acid, all with anti-inflammatory effects. | epigallocatechin gallate | proprotein convertase subtilisin/kexin type 6 | Homo sapiens |
| 5 | Inflammation, enhanced by these lipid oxidation products, plays a key role in the up-regulation of PCSK6 activity as demonstrated by cell pretreatment with NS-398, with epigallocatechin gallate or with acetylsalicylic acid, all with anti-inflammatory effects. | Aspirin | proprotein convertase subtilisin/kexin type 6 | Homo sapiens |
| 6 | For the first time, we demonstrated that both oxysterols and HNE, which substantially accumulate in the atherosclerotic plaque, up-regulate the activity of PCSK6. | Oxysterols | proprotein convertase subtilisin/kexin type 6 | Homo sapiens |
| 7 | For the first time, we demonstrated that both oxysterols and HNE, which substantially accumulate in the atherosclerotic plaque, up-regulate the activity of PCSK6. | 4-hydroxy-2-nonenal | proprotein convertase subtilisin/kexin type 6 | Homo sapiens |