Title : Development of selectivity of alpha1-antitrypsin variant by mutagenesis in its reactive site loop against proprotein convertase. A crucial role of the P4 arginine in PACE4 inhibition.

Pub. Date : 2002 Feb

PMID : 11917148






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 A crucial role of the P4 arginine in PACE4 inhibition. Arginine proprotein convertase subtilisin/kexin type 6 Homo sapiens
2 PACE4, furin and PC6 are Ca2+-dependent serine endoproteases that belong to the subtilisin-like proprotein convertase (SPC) family. Serine proprotein convertase subtilisin/kexin type 6 Homo sapiens