Pub. Date : 1997 Feb 1
PMID : 9032441
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 97 kDa); the N-terminal propeptide cleavage is accelerated in a truncated form of PACE4 lacking the Cys-rich C-terminal region (PACE4s). | propeptide | proprotein convertase subtilisin/kexin type 6 | Homo sapiens |
| 2 | 97 kDa); the N-terminal propeptide cleavage is accelerated in a truncated form of PACE4 lacking the Cys-rich C-terminal region (PACE4s). | Cysteine | proprotein convertase subtilisin/kexin type 6 | Homo sapiens |
| 3 | The enzyme activity of PACE4 is distinct from furin and prohormone convertases, both in the marked sensitivity of PACE4 to inhibition by leupeptin and the relative insensitivity of PACE4 to inhibition by Ca2+ chelators and dithiothreitol; PACE4 is not inhibited by the alpha1-antitrypsin Portland variant that is very potent at inhibiting furin. | leupeptin | proprotein convertase subtilisin/kexin type 6 | Homo sapiens |
| 4 | The enzyme activity of PACE4 is distinct from furin and prohormone convertases, both in the marked sensitivity of PACE4 to inhibition by leupeptin and the relative insensitivity of PACE4 to inhibition by Ca2+ chelators and dithiothreitol; PACE4 is not inhibited by the alpha1-antitrypsin Portland variant that is very potent at inhibiting furin. | leupeptin | proprotein convertase subtilisin/kexin type 6 | Homo sapiens |
| 5 | The enzyme activity of PACE4 is distinct from furin and prohormone convertases, both in the marked sensitivity of PACE4 to inhibition by leupeptin and the relative insensitivity of PACE4 to inhibition by Ca2+ chelators and dithiothreitol; PACE4 is not inhibited by the alpha1-antitrypsin Portland variant that is very potent at inhibiting furin. | leupeptin | proprotein convertase subtilisin/kexin type 6 | Homo sapiens |
| 6 | The enzyme activity of PACE4 is distinct from furin and prohormone convertases, both in the marked sensitivity of PACE4 to inhibition by leupeptin and the relative insensitivity of PACE4 to inhibition by Ca2+ chelators and dithiothreitol; PACE4 is not inhibited by the alpha1-antitrypsin Portland variant that is very potent at inhibiting furin. | leupeptin | proprotein convertase subtilisin/kexin type 6 | Homo sapiens |
| 7 | The enzyme activity of PACE4 is distinct from furin and prohormone convertases, both in the marked sensitivity of PACE4 to inhibition by leupeptin and the relative insensitivity of PACE4 to inhibition by Ca2+ chelators and dithiothreitol; PACE4 is not inhibited by the alpha1-antitrypsin Portland variant that is very potent at inhibiting furin. | Dithiothreitol | proprotein convertase subtilisin/kexin type 6 | Homo sapiens |