palmitoyl-protein thioesterase 1 ; Homo sapiens






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1 7684936 The polypurine tract, PPT, of HIV as target for antisense and triple-helix-forming oligonucleotides. Biochimie 1993 6
2 8633062 Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis. Proc Natl Acad Sci U S A 1996 Apr 30 2
3 8786130 cDNA and genomic cloning of human palmitoyl-protein thioesterase (PPT), the enzyme defective in infantile neuronal ceroid lipofuscinosis. Genomics 1996 Jun 15 2
4 8798525 Purification of a protein palmitoyltransferase that acts on H-Ras protein and on a C-terminal N-Ras peptide. J Biol Chem 1996 Sep 20 3
5 8895569 Human palmitoyl protein thioesterase: evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosis. EMBO J 1996 Oct 1 1
6 9151310 From locus to cellular disturbances: positional cloning of the infantile neuronal ceroid lipofuscinosis gene. Neuropediatrics 1997 Feb 1
7 9151315 The mechanism and functional roles of protein palmitoylation in the nervous system. Neuropediatrics 1997 Feb 3
8 9151317 Low molecular weight storage material in infantile ceroid lipofuscinosis (CLN1). Neuropediatrics 1997 Feb 3
9 9151331 Lamotrigine therapy in infantile neuronal ceroid lipofuscinosis (INCL). Neuropediatrics 1997 Feb 3
10 9160164 Gating of the skeletal calcium release channel by ATP is inhibited by protein phosphatase 1 but not by Mg2+. Cell Calcium 1997 Apr 3
11 9425237 Mutations in the palmitoyl-protein thioesterase gene (PPT; CLN1) causing juvenile neuronal ceroid lipofuscinosis with granular osmiophilic deposits. Hum Mol Genet 1998 Feb 1
12 9571187 A novel insertion mutation (A169i) in the CLN1 gene is associated with infantile neuronal ceroid lipofuscinosis in an Italian patient. Biochem Biophys Res Commun 1998 Apr 17 2
13 9648881 Enzymatic and molecular biological analysis of palmitoyl protein thioesterase deficiency in infantile neuronal ceroid lipofuscinosis. J Neurochem 1998 Jul 2
14 9671519 The antiproliferative agent didemnin B uncompetitively inhibits palmitoyl protein thioesterase. Biochemistry 1998 Jul 21 5
15 10191108 A rapid fluorogenic palmitoyl-protein thioesterase assay: pre- and postnatal diagnosis of INCL. Mol Genet Metab 1999 Apr 2
16 10417332 Characterization of a human MHC class III region gene product with S-thioesterase activity. Biochem J 1999 Aug 1 1
17 10649418 In(8)(C(6)H(3)-2,6-Mes(2))(4) (Mes=C(6)H(2)-2,4,6-Me(3)): A Metal-Rich Main-Group Cluster with a Distorted Cubane Structure. Angew Chem Int Ed Engl 2000 Jan 1
18 10658183 In vitro depalmitoylation of neurospecific peptides: implication for infantile neuronal ceroid lipofuscinosis. J Neurosci Res 2000 Jan 1 10
19 10737604 Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells. J Neurochem 2000 Apr 3
20 10781062 The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis. Proc Natl Acad Sci U S A 2000 Apr 25 3
21 10801859 Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride. J Biol Chem 2000 Aug 4 12
22 10874636 A new simple enzyme assay for pre- and postnatal diagnosis of infantile neuronal ceroid lipofuscinosis (INCL) and its variants. J Med Genet 1999 Jun 1
23 11020216 Antisense palmitoyl protein thioesterase 1 (PPT1) treatment inhibits PPT1 activity and increases cell death in LA-N-5 neuroblastoma cells. J Neurosci Res 2000 Oct 15 7
24 11085596 CLN-encoded proteins do not interact with each other. Neurogenetics 2000 Sep 1
25 11136716 Palmitoyl protein thioesterase (PPT) localizes into synaptosomes and synaptic vesicles in neurons: implications for infantile neuronal ceroid lipofuscinosis (INCL). Hum Mol Genet 2001 Jan 1 1
26 11332777 Positional candidate gene cloning of CLN1. Adv Genet 2001 4
27 11440996 Biochemical analysis of mutations in palmitoyl-protein thioesterase causing infantile and late-onset forms of neuronal ceroid lipofuscinosis. Hum Mol Genet 2001 Jun 15 1
28 11588986 Altered levels of high-energy phosphate compounds in fibroblasts from different forms of neuronal ceroid lipofuscinoses: further evidence for mitochondrial involvement. Eur J Paediatr Neurol 2001 1
29 11588992 Transdermal fentanyl therapy for pains in children with infantile neuronal ceroid lipofuscinosis. Eur J Paediatr Neurol 2001 1
30 11589008 Role of palmitoyl-protein thioesterase in cell death: implications for infantile neuronal ceroid lipofuscinosis. Eur J Paediatr Neurol 2001 8
31 11673581 Hematopoietic stem cell transplantation in infantile neuronal ceroid lipofuscinosis. Neurology 2001 Oct 23 1
32 11921051 Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons. Ann Neurol 2002 Apr 2
33 12359364 Anti-tumor promoting effects of palmitoyl: protein thioesterase inhibitors against a human neurotumor cell line. Cancer Lett 2002 Dec 10 3
34 12603829 Analysis of phospholipid molecular species in brains from patients with infantile and juvenile neuronal-ceroid lipofuscinosis using liquid chromatography-electrospray ionization mass spectrometry. J Neurochem 2003 Mar 11
35 14997940 The intracellular location and function of proteins of neuronal ceroid lipofuscinoses. Brain Pathol 2004 Jan 1
36 15075260 pdf1, a palmitoyl protein thioesterase 1 Ortholog in Schizosaccharomyces pombe: a yeast model of infantile Batten disease. Eukaryot Cell 2004 Apr 3
37 15293392 ppt level detection of samarium(III) with a coated graphite sensor based on an antibiotic. Anal Sci 2004 Jul 1
38 15352223 High-resolution magic angle spinning and 1H magnetic resonance spectroscopy reveal significantly altered neuronal metabolite profiles in CLN1 but not in CLN3. J Neurosci Res 2004 Sep 1 5
39 15859345 [Isolation of the capsid protein gene of maize dwarf mosaic virus and its transformation in maize]. Sheng Wu Gong Cheng Xue Bao 2005 Jan 1
40 15912235 Determination of trace silica in highly purified water based on delayed quenching of Rhodamine B through nanoparticle formation with molybdosilicate. Analyst 2005 Jun 3
41 15929065 Differential regulation of ceramide in lipid-rich microdomains (rafts): antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2. J Neurosci Res 2005 Jul 15 6
42 16364693 CNS-directed AAV2-mediated gene therapy ameliorates functional deficits in a murine model of infantile neuronal ceroid lipofuscinosis. Mol Ther 2006 Mar 1
43 16601878 Inefficient cleavage of palmitoyl-protein thioesterase (PPT) substrates by aminothiols: implications for treatment of infantile neuronal ceroid lipofuscinosis. J Inherit Metab Dis 2006 Feb 12
44 16627894 Thematic review series: lipid posttranslational modifications. Lysosomal metabolism of lipid-modified proteins. J Lipid Res 2006 Jul 2
45 17565660 Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1)--distinct characteristics in neurons. BMC Cell Biol 2007 Jun 12 1
46 18317235 CLN3p impacts galactosylceramide transport, raft morphology, and lipid content. Pediatr Res 2008 Jun 4
47 19933275 Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase. J Biol Chem 2010 Jan 15 1
48 20036592 Human recombinant palmitoyl-protein thioesterase-1 (PPT1) for preclinical evaluation of enzyme replacement therapy for infantile neuronal ceroid lipofuscinosis. Mol Genet Metab 2010 Apr 2
49 21224254 Disruption of adaptive energy metabolism and elevated ribosomal p-S6K1 levels contribute to INCL pathogenesis: partial rescue by resveratrol. Hum Mol Genet 2011 Mar 15 3
50 21702491 Solvent dependent fluorescent properties of a 1,2,3-triazole linked 8-hydroxyquinoline chemosensor: tunable detection from zinc(II) to iron(III) in the CH3CN/H2O system. J Phys Chem A 2011 Jul 28 5