Pub. Date : 1998 Jul 21
PMID : 9671519
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | While the palmitoyl protein thioesterase(s) responsible for depalmitoylation of plasma membrane-associated signaling proteins has (have) not been identified, the lysosomal palmitoyl protein thioesterase 1 (PPT1) has proven useful in in vitro studies of membrane localization requirements of GTP-binding proteins. | Guanosine Triphosphate | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 2 | While the palmitoyl protein thioesterase(s) responsible for depalmitoylation of plasma membrane-associated signaling proteins has (have) not been identified, the lysosomal palmitoyl protein thioesterase 1 (PPT1) has proven useful in in vitro studies of membrane localization requirements of GTP-binding proteins. | Guanosine Triphosphate | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 3 | Didemnin B was shown to inhibit recombinant human PPT1 with a Ki of 92 nM. | didemnins | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 4 | Kinetic analysis of this inhibition revealed that didemnin B inhibits PPT1 uncompetitively. | didemnins | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 5 | As the first described inhibitor of PPT1, didemnin B may prove to be a useful tool in the investigation of protein palmitoylation regulation. | didemnins | palmitoyl-protein thioesterase 1 | Homo sapiens |