Pub. Date : 2003 Mar
PMID : 12603829
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phospholipids (PL) in cerebral cortex from patients with infantile (INCL or CLN1) and juvenile (JNCL or CLN3) forms of neuronal ceroid-lipofuscinosis (NCL) and controls were analysed by normal phase HPLC and on-line electrospray ionization ion-trap mass spectrometric detection (LC-ESI-MS). | Phospholipids | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 2 | Phospholipids (PL) in cerebral cortex from patients with infantile (INCL or CLN1) and juvenile (JNCL or CLN3) forms of neuronal ceroid-lipofuscinosis (NCL) and controls were analysed by normal phase HPLC and on-line electrospray ionization ion-trap mass spectrometric detection (LC-ESI-MS). | Phospholipids | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 3 | Compared with the controls, the INCL brains contained proportionally more phosphatidylcholine (PC), and less phosphatidylethanolamine (PE) and phosphatidylserine (PS). | Phosphatidylcholines | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 4 | Compared with the controls, the INCL brains contained proportionally more phosphatidylcholine (PC), and less phosphatidylethanolamine (PE) and phosphatidylserine (PS). | Phosphatidylcholines | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 5 | Compared with the controls, the INCL brains contained proportionally more phosphatidylcholine (PC), and less phosphatidylethanolamine (PE) and phosphatidylserine (PS). | phosphatidylethanolamine | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 6 | Compared with the controls, the INCL brains contained proportionally more phosphatidylcholine (PC), and less phosphatidylethanolamine (PE) and phosphatidylserine (PS). | phosphatidylethanolamine | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 7 | Compared with the controls, the INCL brains contained proportionally more phosphatidylcholine (PC), and less phosphatidylethanolamine (PE) and phosphatidylserine (PS). | Phosphatidylserines | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 8 | Compared with the controls, the INCL brains contained proportionally more phosphatidylcholine (PC), and less phosphatidylethanolamine (PE) and phosphatidylserine (PS). | Phosphatidylserines | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 9 | In INCL cortex, which had lost 65% of the normal PL content, the proportions of polyunsaturated molecular species, especially the PS and PE that contained docosahexaenoic acid (22:6n-3), were dramatically decreased. | Docosahexaenoic Acids | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 10 | Lysobisphosphatidic acid was highly elevated in the INCL brain and consisted mostly of polyunsaturated species. | bis(monoacylglyceryl)phosphate | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 11 | It is possible that changes in the composition of PL membranes accelerate progression of INCL by altering signalling and membrane trafficking in neurons. | Phospholipids | palmitoyl-protein thioesterase 1 | Homo sapiens |