Pub. Date : 2004 Apr
PMID : 15075260
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Infantile Batten disease is a severe neurodegenerative storage disorder caused by mutations in the human PPT1 (palmitoyl protein thioesterase 1) gene, which encodes a lysosomal hydrolase that removes fatty acids from lipid-modified proteins. | Fatty Acids | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 2 | Infantile Batten disease is a severe neurodegenerative storage disorder caused by mutations in the human PPT1 (palmitoyl protein thioesterase 1) gene, which encodes a lysosomal hydrolase that removes fatty acids from lipid-modified proteins. | Fatty Acids | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 3 | Inactivating mutations in the Dolpp1p domain do not rescue the lethality, whereas mutations in the Ppt1p domain result in cells that are viable but abnormally sensitive to sodium orthovanadate and elevated extracellular pH. | Sodium orthovanadate | palmitoyl-protein thioesterase 1 | Homo sapiens |