Title : Differential regulation of ceramide in lipid-rich microdomains (rafts): antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2.

Pub. Date : 2005 Jul 15

PMID : 15929065






6 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Overexpression of palmitoyl:protein thioesterase (PPT1; verified by Western blot of the V5-tagged protein and increased enzyme activity) resulted in decreased ceramide in the detergent-resistant microdomain (DRM, or raft) relative to cholesterol and sphingomyelin (SM). Ceramides palmitoyl-protein thioesterase 1 Homo sapiens
2 Overexpression of palmitoyl:protein thioesterase (PPT1; verified by Western blot of the V5-tagged protein and increased enzyme activity) resulted in decreased ceramide in the detergent-resistant microdomain (DRM, or raft) relative to cholesterol and sphingomyelin (SM). Cholesterol palmitoyl-protein thioesterase 1 Homo sapiens
3 Overexpression of palmitoyl:protein thioesterase (PPT1; verified by Western blot of the V5-tagged protein and increased enzyme activity) resulted in decreased ceramide in the detergent-resistant microdomain (DRM, or raft) relative to cholesterol and sphingomyelin (SM). Sphingomyelins palmitoyl-protein thioesterase 1 Homo sapiens
4 Overexpression of palmitoyl:protein thioesterase (PPT1; verified by Western blot of the V5-tagged protein and increased enzyme activity) resulted in decreased ceramide in the detergent-resistant microdomain (DRM, or raft) relative to cholesterol and sphingomyelin (SM). Sphingomyelins palmitoyl-protein thioesterase 1 Homo sapiens
5 This PPT1 overexpression also resulted in protection against cell death induced by either staurosporine or C(2)-ceramide. Staurosporine palmitoyl-protein thioesterase 1 Homo sapiens
6 This PPT1 overexpression also resulted in protection against cell death induced by either staurosporine or C(2)-ceramide. N-acetylsphingosine palmitoyl-protein thioesterase 1 Homo sapiens