Pub. Date : 2002 Dec 10
PMID : 12359364
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We chemically synthesized a non-hydrolyzable analog of the palmitoyl-cysteine thioester linkage (AcG-alpha-ketoamido-palmitoyl diamino propionate-VKIKK) (DAPKA) and showed that it inhibits palmitoyl:protein thioesterase (PPT1) in an in vitro assay using a specific fluorescent-based (4-methylumbelliferyl-beta-gluco-6-thiopalmitate) assay. | palmitoyl-cysteine thioester | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 2 | Overexpression of PPT1 protected against apoptosis induced by etoposide and the ketoamide and the inhibitory effect of the two was additive. | Etoposide | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 3 | Overexpression of PPT1 protected against apoptosis induced by etoposide and the ketoamide and the inhibitory effect of the two was additive. | oxoazanide | palmitoyl-protein thioesterase 1 | Homo sapiens |