Pub. Date : 2000 Jan 1
PMID : 10658183
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Palmitoyl protein thioesterase 1 (PPT1) removes palmitate from specific cysteine residues in peptides and proteins. | Palmitates | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 2 | Palmitoyl protein thioesterase 1 (PPT1) removes palmitate from specific cysteine residues in peptides and proteins. | Palmitates | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 3 | Palmitoyl protein thioesterase 1 (PPT1) removes palmitate from specific cysteine residues in peptides and proteins. | Cysteine | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 4 | Palmitoyl protein thioesterase 1 (PPT1) removes palmitate from specific cysteine residues in peptides and proteins. | Cysteine | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 5 | To characterize further the substrate specificity of PPT1, we prepared various palmitoylated oligopeptides, based on palmitoylated sequences from different proteins. | Oligopeptides | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 6 | LA-N-5 human neuroblastoma cells overexpressing PPT1 showed increased depalmitoylation of all the peptide substrates, indicating that these peptides are deacylated by PPT1. | la-n-5 | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 7 | LA-N-5 human neuroblastoma cells overexpressing PPT1 showed increased depalmitoylation of all the peptide substrates, indicating that these peptides are deacylated by PPT1. | la-n-5 | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 8 | An amide derivative of a palmitoylated K-Ras peptide (AcG-palmitoyl diamino propionate-VKIKK) acted as an enzyme pseudosubstrate and inhibited PPT1 enzyme activity in a dose-dependent manner. | Amides | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 9 | An amide derivative of a palmitoylated K-Ras peptide (AcG-palmitoyl diamino propionate-VKIKK) acted as an enzyme pseudosubstrate and inhibited PPT1 enzyme activity in a dose-dependent manner. | acg-palmitoyl diamino propionate | palmitoyl-protein thioesterase 1 | Homo sapiens |
| 10 | In summary, PPT1 is able to hydrolyze a range of cysteinyl peptide sequences found in both neuron-specific and ubiquitous (e.g., Galpha) proteins. | cysteinyl peptide | palmitoyl-protein thioesterase 1 | Homo sapiens |