peroxisome proliferative activated receptor, gamma, coactivator 1 alpha ; Mus musculus






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1 11018072 Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest 2000 Oct 1
2 11557972 Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 2001 Sep 13 4
3 11557984 CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 2001 Sep 13 1
4 12195019 PPAR alpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue. Proc Natl Acad Sci U S A 2002 Sep 3 1
5 12234291 Alterations of PPARalpha and its coactivator PGC-1 in cisplatin-induced acute renal failure. Kidney Int 2002 Oct 5
6 12444247 AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci U S A 2002 Dec 10 1
7 12574632 Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science 2003 Feb 7 1
8 12578979 Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha ) and mitochondrial function by MEF2 and HDAC5. Proc Natl Acad Sci U S A 2003 Feb 18 1
9 12852853 Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell 2003 Jul 2
10 12865425 Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle. J Biol Chem 2003 Oct 3 1
11 14522988 PGC-1alpha activates CYP7A1 and bile acid biosynthesis. J Biol Chem 2003 Dec 12 5
12 14614508 CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma. Nature 2003 Nov 13 2
13 14726475 Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Circ Res 2004 Mar 5 11
14 14729567 Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR. Genes Dev 2004 Jan 15 6
15 15024092 p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol Cell Biol 2004 Apr 2
16 15107844 PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med 2004 May 1
17 15151904 Real-time imaging of peroxisome proliferator-activated receptor-gamma coactivator-1alpha promoter activity in skeletal muscles of living mice. Am J Physiol Cell Physiol 2004 Sep 1
18 15456881 Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol Cell Biol 2004 Oct 2
19 15671906 Role of the liver in the control of carbohydrate and lipid homeostasis. Diabetes Metab 2004 Nov 1
20 15767263 Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. J Biol Chem 2005 May 20 1
21 15878932 Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle. FASEB J 2005 Jul 4
22 16025253 Short-term inhibition of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression reverses diet-induced diabetes mellitus and hepatic steatosis in mice. Diabetologia 2005 Sep 4
23 16054070 Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab 2005 Apr 1
24 16061943 Suppression of estrogen-related receptor alpha and medium-chain acyl-coenzyme A dehydrogenase in the acute-phase response. J Lipid Res 2005 Oct 2
25 16122419 Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell 2005 Aug 26 5
26 16205884 Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat. Diabetologia 2005 Nov 1
27 16223979 Inverse relationship between PGC-1alpha protein expression and triacylglycerol accumulation in rodent skeletal muscle. J Appl Physiol (1985) 2006 Feb 3
28 16364253 AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1. Biochem Biophys Res Commun 2006 Feb 3 3
29 16424281 Peroxisome proliferator-activated receptor gamma coactivator 1 in caloric restriction and other models of longevity. J Gerontol A Biol Sci Med Sci 2005 Dec 3
30 16574644 Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism. J Biol Chem 2006 May 26 2
31 16670093 Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice. J Biol Chem 2006 Jul 14 8
32 16753578 GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. Cell Metab 2006 Jun 1
33 16775082 Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha. Proc Natl Acad Sci U S A 2006 Jun 27 1
34 16908541 Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activation. Mol Cell Biol 2006 Oct 2
35 16950137 Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab 2006 Sep 4
36 17003343 Palmitate-mediated downregulation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha in skeletal muscle cells involves MEK1/2 and nuclear factor-kappaB activation. Diabetes 2006 Oct 8
37 17003473 Overexpression of peroxisome proliferator-activated receptor gamma co-activator-1alpha leads to muscle atrophy with depletion of ATP. Am J Pathol 2006 Oct 1
38 17030788 Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1alpha. Proc Natl Acad Sci U S A 2006 Oct 17 3
39 17055439 Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 2006 Oct 20 10
40 17055784 Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration. Cell Metab 2006 Nov 1
41 17086191 Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006 Nov 16 2
42 17093946 Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice. Diabetologia 2007 Jan 1
43 17112576 Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006 Dec 15 5
44 17174885 In vino veritas: a tale of two sirt1s? Cell 2006 Dec 15 1
45 17182725 Pyruvate induces mitochondrial biogenesis by a PGC-1 alpha-independent mechanism. Am J Physiol Cell Physiol 2007 May 2
46 17261654 Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway. Circulation 2007 Feb 20 1
47 17290224 Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo. EMBO J 2007 Feb 21 1
48 17390079 Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner. Int J Mol Med 2007 May 1
49 17416903 Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. J Biol Chem 2007 May 25 8
50 17446185 An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation. Endocrinology 2007 Jul 4