Title : An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation.

Pub. Date : 2007 Jul

PMID : 17446185






4 Functional Relationships(s)
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1 In C57BL/6J mice, injection of the beta2-AR agonist clenbuterol, but not alpha-, beta1-, or beta3-AR agonists, increased PGC-1alpha mRNA expression more than 30-fold in skeletal muscle. Clenbuterol peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus
2 The clenbuterol-induced increase in PGC-1alpha mRNA expression in mice was inhibited by pretreatment with the beta-AR antagonist propranolol. Clenbuterol peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus
3 The clenbuterol-induced increase in PGC-1alpha mRNA expression in mice was inhibited by pretreatment with the beta-AR antagonist propranolol. Propranolol peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus
4 The exercise-induced increase in PGC-1alpha mRNA was inhibited by approximately 70% by propranolol or the beta2-AR-specific inhibitor ICI 118,551. Propranolol peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus